ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025
Irisin deficiency exacerbates cardiac dysfunction and enhances hemorrhage injury in hemorrhage/resuscitation.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Irisin contributes critically to modulating metabolism and tissue survival in muscles and adipocytes. Whether deficiency of irisin impacts the hemorrhagic injury and/or whether the effect of irisin deficiency on hemorrhagic injury primarily relies on irisin, which is currently unknown. We use an irisin knockout mouse to eliminate irisin and pharmacological approaches in a mouse hemorrhagic model to determine the function of irisin on hemorrhage and resuscitation (H/R). Hemorrhage was induced by achieving a mean arterial blood pressure of 35-45 mmHg for 60 min, followed by 2 h of resuscitation in mice. Experimental groups were divided as follows (
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