Evidence map›Paper›PMID 41092257›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2025

Clinical Spectrum, Pathology, and Mechanisms of Anti-LGI4 Antibody-Positive Autoimmune Nodopathy.

Xu Zhang, Jun-Ichi Kira, Akira Yokote, Ayako Sakoda, Ken-Ichiro Yamashita, Mikio Mitsuishi, Hidenori Ogata, Takumi Tashiro, Noriko Isobe, Ryota Sato and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Xu ZhangTranslational Neuroscience Research Center, Graduate School of Medicine, International University of Health and Welfare, Okawa, Japan.
Jun-Ichi KiraTranslational Neuroscience Research Center, Graduate School of Medicine, International University of Health and Welfare, Okawa, Japan.ORCID 0000-0001-5307-2671
Akira YokoteDepartment of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Fukuoka, Japan.
Ayako SakodaDepartment of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Fukuoka, Japan.
Ken-Ichiro YamashitaDepartment of Neurology, Brain and Nerve Center, Fukuoka Central Hospital, International University of Health and Welfare, Fukuoka, Japan.
Mikio MitsuishiTranslational Neuroscience Research Center, Graduate School of Medicine, International University of Health and Welfare, Okawa, Japan.
Hidenori OgataDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0001-8932-9731
Takumi TashiroDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0009-0007-6528-4306
Noriko IsobeDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0001-9525-4254
Ryota SatoDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan.ORCID 0000-0003-1691-1776
Takashi KandaDepartment of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Japan.ORCID 0000-0001-8919-6377
Toshihiro IdeDivision of Neurology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.
Haruki KoikeDivision of Neurology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.ORCID 0000-0002-4612-3183
Takayasu MishimaDepartment of Neurology, Faculty of Medicine, Fukuoka University, Japan.
Yoshio TsuboiDepartment of Neurology, Faculty of Medicine, Fukuoka University, Japan.ORCID 0000-0002-6758-0981
Masaki KobayashiDepartment of Neurology, Tokyo Women's Medical University Hospital, Japan.
Kazuo KitagawaDepartment of Neurology, Tokyo Women's Medical University Hospital, Japan.ORCID 0000-0002-7669-231X
Yukihiro NamihiraDepartment of Cardiovascular Medicine, Nephrology, and Neurology, Graduate School of Medicine, University of Ryukyus, Okinawa, Japan.
Yusuke OhyaDepartment of Cardiovascular Medicine, Nephrology, and Neurology, Graduate School of Medicine, University of Ryukyus, Okinawa, Japan.
Yuko FukataDivision of Molecular and Cellular Pharmacology, Nagoya University Graduate School of Medicine, Japan; and.ORCID 0000-0001-7724-8643
Masaki FukataDivision of Neuropharmacology, Nagoya University Graduate School of Medicine, Japan.ORCID 0000-0001-5200-9806
Tomohiro ImamuraTranslational Neuroscience Research Center, Graduate School of Medicine, International University of Health and Welfare, Okawa, Japan.
Guzailiayi MaimaitijiangTranslational Neuroscience Research Center, Graduate School of Medicine, International University of Health and Welfare, Okawa, Japan.ORCID 0000-0003-3285-2462
Yuri NakamuraTranslational Neuroscience Research Center, Graduate School of Medicine, International University of Health and Welfare, Okawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe aim of this study was to elucidate the clinical spectrum and mechanisms of autoimmune nodopathy (AN) with autoantibodies against leucine-rich repeat leucin-rich glioma inactivated 1 (LGI) family member 4 (LGI4) localized at juxtaparanodes and satellite glia in the dorsal root ganglion.

methodsWe developed a live cell-based assay for LGI4-immunoglobulin (Ig) G and surveyed 131 patients with chronic inflammatory demyelinating polyneuropathy. LGI4-IgG, anti-LGI4 antibody-negative CIDP-IgG, or healthy control (HC)-IgG were applied to Schwann cells, and cell proliferation was assayed using 5-bromo-2'-deoxyuridine labeling. Quantitative real-time PCR was used to assess the expression of

resultsEight anti-LGI4 antibody-positive (LGI4 DISCUSSION: LGI4

Indexed as

AutoantibodiesPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingAdultAgedAged, 80 and overAnimalsFemaleGanglia, SpinalHumansImmunoglobulin GMaleMiceMiddle AgedSchwann CellsAutoantibodiesImmunoglobulin G

Identifiers

PMID41092257
PMCPMC12552057

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.