Evidence map›Paper›PMID 41092208›Full record

SynthesisArquivos brasileiros de oftalmologia2025

Perioperative subconjunctival steroid injection in dropless cataract surgery: a systematic review and meta-analysis.

Laura Goldfarb Cyrino, Dillan Amaral, Alexandre Yamada Fujimura Júnior, Bela J Parekh, Marcela Marino de Azeredo Bastos, Giovana de Souza Gaio, Maria Antônia Torres Arteche, Amanda Souza do Nascimento, Vitor Expedito Alves Ribeiro, Jaime Guedes and 1 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Arquivos brasileiros de oftalmologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura Goldfarb CyrinoUniversidade de São Paulo, São Paulo, SP, Brazil.ORCID 0000-0001-6007-6662
Dillan AmaralUniversidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID 0009-0002-7948-154X
Alexandre Yamada Fujimura JúniorFaculdade de Medicina de Marília, Marília, SP, Brazil.ORCID 0009-0009-0839-8272
Bela J ParekhWills Eye Hospital, Philadelphia, PA, USA.ORCID 0000-0002-7340-0297
Marcela Marino de Azeredo BastosUniversidade de São Paulo, São Paulo, SP, Brazil.ORCID 0009-0006-9099-4687
Giovana de Souza GaioUniversidade da Região de Joinville, Joinville, SC, Brazil.ORCID 0000-0003-2942-1805
Maria Antônia Torres ArtecheUniversidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.ORCID 0000-0003-2366-1656
Amanda Souza do NascimentoUniversidade Estadual de Londrina, Londrina, PR, Brazil.ORCID 0000-0001-6300-1455
Vitor Expedito Alves RibeiroUniversidade Federal do Piauí, Teresina, PI, Brazil.ORCID 0000-0002-9275-0954
Jaime GuedesGlaucoma Research Center, Wills Eye Hospital, Philadelphia, PA, USA.ORCID 0000-0002-8174-8082
Marianna Almeida HollaenderUniversidade de São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-1590-3523

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advantages and disadvantages of using perioperative subconjunctival steroid injections in dropless cataract surgery continue to be debated. A systematic review of PubMed, EMBASE, and the Cochrane Central database identified five studies-two randomized controlled trials and three non-randomized studies-encompassing 70,751 eyes. Among these, 12,319 eyes (17.4%) received subconjunctival steroid injections, while 58,432 eyes (82.6%) were managed with topical steroids. The Cochrane Collaboration's RoB 2 tool was applied for bias assessments in randomized controlled trials, and heterogeneity was assessed using the I² statistics. No statistically significant differences were found between the two groups regarding macular edema (p=0.249), visual acuity (p=0.73), or laser flare count (p=0.45). Both subconjunctival injections and topical steroids demonstrated comparable efficacy and safety in controlling postoperative inflammation after cataract surgery. Additional research is warranted to validate these conclusions.

Indexed as

Cataract ExtractionSteroidsConjunctivaHumansInjections, IntraocularPerioperative CarePostoperative ComplicationsRandomized Controlled Trials as TopicTreatment OutcomeVisual AcuitySteroids

Identifiers

PMID41092208
PMCPMC12997625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.