ArticlePlant physiology2025
Natural allelic variation in the CBF2 transcription factor is a pivotal factor controlling cold resistance in potato.
Article in Plant physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Converging GWAS and Genome Editing Decrypts MsCBF8-MsGolS2 Regulatory Module for Drought Tolerance Without Yield Penalty in Medicago sativa.Plant biotechnology journal · 2026Article
- VaWRKY26 transcription factor from Vitis amurensis negatively regulates plant cold tolerance.Planta · 2026Article
- Comprehensive Evaluation of Mung Bean Germplasm Resources Based on DUS Test Characteristics.Plants (Basel, Switzerland) · 2026Article
- Molecular mechanisms of plant freezing tolerance: from cold signal perception to adaptive responses.Frontiers in plant science · 2026Review
- Research progress on cold tolerance key genes and mechanisms in four major northern China crops.Frontiers in plant science · 2026Review
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Authors and funding
13 authors.
Funding
Abstract
Frost stress poses a serious threat to the potato industry. C-repeat binding factors (CBFs) are key transcription factors involved in plant cold responses and the adaptive evolution of land plants. However, their function and underlying mechanisms in potato remain poorly understood. This study analyzed homologous CBF2 genes from 46 potato genotypes and revealed significant structural variations, including a critical site (site A) that is closely associated with cold tolerance. There are at least 2 site A types, including the cold-tolerant Solanum commersonii type and the cold-sensitive Solanum tuberosum type. Overexpression of ScCBF2 significantly enhanced potato cold tolerance, whereas StCBF2 overexpression had a limited effect. We demonstrated that both ScCBF2 and StCBF2 improve cold resistance by regulating glutathione S-transferase tau (GSTU)- and ZAT10-mediated reactive oxygen species scavenging systems. Notably, ScCBF2 uniquely upregulated Galactinol synthase 3 (GolS3), promoting raffinose biosynthesis. Compared with StCBF2, ScCBF2 exhibited a stronger binding affinity to the GolS3 promoter, resulting in higher transcriptional activation. Overexpression of ScGolS3 increased leaf raffinose content and cold tolerance. Furthermore, we confirmed the critical role of site A in the ScCBF2-GolS3 regulatory pathway. In summary, this study highlights the functional divergence caused by structural variations in CBF2, with differential regulation of GolS3 contributing to cold tolerance. Our work provides insights into the molecular mechanisms underlying cold tolerance in potato and offers potential targets for improving frost resistance in this vital crop.
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