ArticleJournal of animal science2025
Comprehensive transcriptomic profiling of dynamic endometrial alterations during different implantation stages in goats (Capra hircus).
Article in Journal of animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Multi-omics profiling of chromatin accessibility and H3K27ac reveals super-enhancer-mediated regulatory networks governing endometrial receptivity in goats.Journal of animal science and biotechnology · 2026Article
- Analysis of miRNA Expression in Bovine Endometrium During the Estrous Cycle.Animal science journal = Nihon chikusan GakkaihoArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The establishment of endometrial receptivity constitutes a multifaceted biological process orchestrated by intricate regulatory networks, representing a critical determinant for successful embryo implantation and pregnancy outcomes. This study systematically characterized the dynamic landscapes of non-coding RNA (ncRNA) and mRNA in the goat endometrium across distinct implantation stages. Endometrial tissues from goats at gestational days 10 (D10, n = 4), 17 (D17, n = 4), and pregnancy failure at gestational day 17 (PF, n = 3) were collected; in addition, three samples from each group (n = 3) were selected for transcriptomic sequencing of mRNA, lncRNA, circRNA, and miRNA. The receptive endometrium (D17) exhibited enhanced glandular development, mature pinopodes, elevated estrogen and progesterone levels, and a reduced estrogen/progesterone ratio, along with upregulated markers (VEGF, OPN, IGF1R). Transcriptome profiling identified 6,104 differentially expressed mRNAs (DEmRNAs), 485 lncRNAs (DElncRNAs), 1,694 circRNAs (DEcircRNAs), and 203 miRNAs (DEmiRNAs) across stages. Functional enrichment analysis highlighted the pivotal roles of MAPK, TNF, and RAS signaling pathways in establishing endometrial receptivity, with hub genes including ISG15, CXCL10, IFI6, and RSAD2 contributing significantly to the development of uterine receptivity in goats. Furthermore, ncRNAs such as MSTRG774.1, novel_circ_000145, novel_circ_000257, and chi-miR-348-3p exhibited specific or elevated expression patterns during the receptive phase, suggesting their potential regulatory functions in maintaining the endometrial receptivity microenvironment. Moreover, an integrated competing endogenous RNA (ceRNA) network was constructed to elucidate potential interactions between ncRNAs and mRNAs, offering novel insights into the molecular regulatory mechanisms underlying endometrial receptivity in ruminants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.