Evidence map›Paper›PMID 41091915›Full record

ArticleScience translational medicine2025

Deletion of the X-chromosomal gene

Yuichiro Itoh, Noriko Itoh, Sophia Wendin, Nadya Higgins, Rhonda R Voskuhl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuichiro ItohDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-7679-0174
Noriko ItohDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-0994-4855
Sophia WendinDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-2627-390X
Nadya HigginsDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0009-0001-8660-7940
Rhonda R VoskuhlDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-2620-4346

Funding

Neurodegeneration Underlying Distinct Disabilities in Multiple Sclerosis Using a Cell-Specific, Region-Specific, and Sex-Specific ApproachR35NS132150 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RHONDA R VOSKUHL · 2023 to 2026
$3.6M
Neuroprotection in MS: A Cell-Specific and Region-Specific Transcriptomics ApproachR01NS109670 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VOSKUHL, RHONDA R · 2018 to 2022
$2.2M
Parental imprinting of the X chromosome: effects on neurodegenerationR01NS096748 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VOSKUHL, RHONDA R · 2016 to 2020
$1.9M
NINDS NIH HHS R01 NS096748NINDS NIH HHS R01 NS109670NINDS NIH HHS R35 NS132150
6 · The paper itself

Abstract

Women are more susceptible to multiple sclerosis (MS) than men, with a reported incidence ratio of ~3:1.

Indexed as

Gene DeletionHistone DemethylasesMicrogliaNeuroinflammatory DiseasesAnimalsEncephalomyelitis, Autoimmune, ExperimentalFemaleMaleMiceMice, Inbred C57BLMultiple SclerosisSpinal CordHistone DemethylasesUtx protein, mouse

Identifiers

PMID41091915
PMCPMC12952533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.