Evidence map›Paper›PMID 41091885›Full record

ArticleScience advances2025

A phosphoinositide switch from PI(4,5)P

Xiaoli Guo, Lisi Wei, Nidhi Kundu, Wonchul Shin, Chung Yu Chan, Sue Han, Ammar Mohseni, Maryam Molakarimi, Min Sun, Xin-Sheng Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Roles in physiology and disease of the inositol phosphatase synaptojanin 1.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoli GuoNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0009-0004-7891-8994
Lisi WeiNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0002-5265-9259
Nidhi KunduStructural Cell Biology Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.ORCID 0000-0002-6282-6217
Wonchul ShinNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Chung Yu ChanNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0001-6726-5087
Sue HanNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0001-8451-8592
Ammar MohseniNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Maryam MolakarimiNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Min SunNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Xin-Sheng WuNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0003-4921-8329
Yinghui JinNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Jenny E HinshawStructural Cell Biology Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.ORCID 0000-0002-5130-5061
Ling-Gang WuNational Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0003-4261-7079

Funding

Synaptic Vesicle ExocytosisZIANS003009 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WU, LING GANG · 2009 to 2025
$31.2M
Synaptic Vesicle EndocytosisZIANS003105 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WU, LING GANG · 2009 to 2025
$30.9M
Structure /Function Of Dynamin, A GTPase in EndocytosisZ01DK060100 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HINSHAW, JENNY E · 1996 to 2008
$657k
Intramural NIH HHS Z01 DK060100Intramural NIH HHS ZIA NS003009Intramural NIH HHS ZIA NS003105
6 · The paper itself

Abstract

Endocytosis generates life-essential vesicles via complex protein-lipid machinery, yet its initiation mechanisms remain elusive. Long thought to require full machinery spatiotemporal coordination to drive the flat-to-round vesicle transformations, we reveal a notably simple initiation mechanism in neuroendocrine chromaffin cells involving only the final step, the pore closure. During calcium-triggered exocytosis, calcium activates the phosphatase synaptojanin, rapidly converting PI(4,5)P

Indexed as

Chromaffin CellsDynaminsEndocytosisPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol PhosphatesPhosphatidylinositolsAnimalsCalciumExocytosisHumansMiceNerve Tissue ProteinsPhosphoric Monoester HydrolasesCalciumDynaminsNerve Tissue ProteinsPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol PhosphatesPhosphatidylinositolsPhosphoric Monoester Hydrolasessynaptojanin

Identifiers

PMID41091885
PMCPMC12526769

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.