ArticleScience advances2025
Bubble-driven cell detachment.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On-demand cell detachment is of great importance in various applications in biosensitive environments. Existing methods such as enzymatic treatments and mechanical scraping are often time-consuming, labor-intensive, and harmful to cells. In this work, we demonstrate a method of detaching cells from substrates using electrochemical bubble generation without biocide generation. We demonstrate that shear stress generated by fluid flow beneath a rising bubble is the primary mechanism for cell detachment. This strategy, relying solely on physical forces and independent of cell or surface chemistry, can therefore work with a large range of the media, surfaces, and cells. We successfully implement this discovery at the lab-scale by designing a prototype for on-demand cell detachment that maintains high cell viability. The developed principle could find applications in high-throughput culture settings, such as algae photobioreactors or cell culture environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.