Evidence map›Paper›PMID 41091852›Full record

ArticleScience progress

Hepatotoxicity of ALK/ROS1 tyrosine kinase inhibitors in non-small cell lung cancer patients: A pharmacovigilance study based on signal mining and analysis of the FDA adverse event reporting system database.

Weixing Zhao, Xiaoni Jin, Yuan Li, Huiyuan Peng, Jun Jiang

Abstract read
In one paragraph

Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weixing ZhaoDepartment of Oncology, Graduate School of Qinghai University, Qinghai, China.ORCID 0009-0001-1291-4788
Xiaoni JinDepartment of Oncology, Graduate School of Qinghai University, Qinghai, China.ORCID 0009-0004-9117-0829
Yuan LiDepartment of Oncology, Graduate School of Qinghai University, Qinghai, China.ORCID 0009-0003-8186-6649
Huiyuan PengDepartment of Oncology, Graduate School of Qinghai University, Qinghai, China.ORCID 0009-0007-6669-493X
Jun JiangDivision III, Department of Medical Oncology, Affiliated Hospital of Qinghai University, Qinghai, China.ORCID 0000-0002-6248-6179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveThis study evaluated the hepatotoxicity risk of anaplastic lymphoma kinase (

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungProtein Kinase InhibitorsAdolescentAdultAgedAged, 80 and overAminopyridinesAnaplastic Lymphoma KinaseCarbazolesChemical and Drug Induced Liver InjuryCrizotinibDatabases, FactualData MiningFemaleHumansalectinibAminopyridinesAnaplastic Lymphoma KinaseAntineoplastic AgentsCarbazolesceritinibCrizotinibLactamslorlatinibPiperidinesProtein Kinase InhibitorsProtein-Tyrosine KinasesProto-Oncogene ProteinsPyrazolesPyrimidinesROS1 protein, humanSulfonesTyrosine Kinase Inhibitorsadverse eventsALK-TKIsFDA adverse event reporting systemhepatotoxicityROS1-TKIs

Identifiers

PMID41091852
PMCPMC12536124

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.