ArticleTechnology in cancer research & treatment
MRI Radiomics-Based Prediction of Occult Sentinel Lymph Node Metastasis and D2-40 Expression in Breast Cancer.
Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
IntroductionPatients with Magnetic Resonance Imaging (MRI) axillary lymph node (ALN) negative in breast cancer may still have occult sentinel lymph node (SLN) metastases, which can influence clinical treatment strategies. This study aimed to develop an MRI-based radiomics model for predicting occult SLN metastases and D2-40 expression, and to investigate the intrinsic associations between D2-40 expression, SLN status, and related radiomics features.MethodsThis retrospective study included 141 MRI-diagnosed ALN-negative breast cancer patients from Center 1, randomly divided into training (n = 98) and validation (n = 43) sets (7:3 ratio). An independent external validation cohort (n = 40) from Centers 1 + 2 was established for model validation. Three logistic regression models were developed: (1) a clinical model, (2) a radiomics model, and (3) a clinic-radiomics nomogram, which predict SLN metastasis (Model 1) and D2-40 expression (Model 2). In addition, the correlation between D2-40 expression and SLN status was analyzed in this study using chi-square test. And the feature correlation between SLN radiomics model and D2-40 radiomics model and the strength of association between D2-40 and Model 1 features were assessed by Spearman and Pearson correlation analysis, respectively.ResultsThe nomogram outperformed the other models in both Model 1 (AUC: 0.821 validation/0.746 external) and Model 2 (AUC: 0.810 validation/0.645 external). D2-40 correlated with SLN status (
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