Evidence map›Paper›PMID 41091768›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Temporal and spatial coordination of DNA segregation and cell division in an archaeon.

Joe Parham, Valerio Sorichetti, Alice Cezanne, Sherman Foo, Yin-Wei Kuo, Baukje Hoogenberg, Arthur Radoux-Mergault, Eloise Mawdesley, Lydia Daniels Gatward, Jerome Boulanger and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Journal of bacteriology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Regulation of eukaryotic-like cell cycle progression in archaea is coming into focus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Joe ParhamDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-1280-5335
Valerio Sorichetti *Institute of Science and Technology Austria, Klosterneuberg 3400, Austria.
Alice Cezanne *Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Sherman FooDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0001-7204-7172
Yin-Wei KuoDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-1038-1228
Baukje HoogenbergDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Arthur Radoux-MergaultDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0001-7425-0350
Eloise MawdesleyDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0009-0004-9356-8144
Lydia Daniels GatwardDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-0902-5664
Jerome BoulangerDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0003-0237-3743
Ulrike SchulzeDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.
Anđela ŠarićInstitute of Science and Technology Austria, Klosterneuberg 3400, Austria.ORCID 0000-0002-7854-2139
Buzz BaumDivision of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-9201-6186

Funding

EC | ERC | HORIZON EUROPE European Research Council (ERC) 802960EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions (MSCA) 101068523European Molecular Biology Organization (EMBO) ALTF_1041-2021European Molecular Biology Organization (EMBO) ALTF_431-2025European Molecular Biology Organization (EMBO) ALTF_903-2021Moore Family Foundation (MFF) 9346Simons Foundation (SF) 735929LPIUKRI | MRC | Medical Research Council Laboratory of Molecular Biology (LMB) MC_UP_1201/27Vallee Foundation (The Vallee Foundation) Andela SaricWellcome TrustWellcome Trust (WT) 203276/A/16/ZWellcome Trust (WT) 222460/Z/21/Z
6 · The paper itself

Abstract

Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segregation and division are mechanistically coupled in archaeal relatives of eukaryotes, which lack Cyclin-dependent kinase (CDK)/Cyclins. Using live cell imaging, we first describe the series of sequential changes in DNA organization that accompany cell division in

Indexed as

Cell DivisionChromosome SegregationDNA, ArchaealSulfolobusArchaeal ProteinsArchaeal ProteinsDNA, Archaealarchaeacell divisioncheckpointchromosome segregationevolution

Identifiers

PMID41091768
PMCPMC12557731

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.