Evidence map›Paper›PMID 41091766›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Invasin-functionalized PIC hydrogels enable long-term 3D culture of epithelial organoids.

Joost J A P M Wijnakker, Sangho Lim, Robin Schreurs, João Ferreira Faria, Jeroen Korving, Harry Begthel, Kirti K Iyer, Paul H J Kouwer, Hans Clevers

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joost J A P M WijnakkerOncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Science (KNAW), Utrecht 3584 CT, The Netherlands.
Sangho LimOncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Science (KNAW), Utrecht 3584 CT, The Netherlands.
Robin SchreursOncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Science (KNAW), Utrecht 3584 CT, The Netherlands.
João Ferreira FariaInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.
Jeroen KorvingOncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Science (KNAW), Utrecht 3584 CT, The Netherlands.
Harry BegthelOncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Science (KNAW), Utrecht 3584 CT, The Netherlands.
Kirti K IyerInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.
Paul H J KouwerInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.
Hans CleversOncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Science (KNAW), Utrecht 3584 CT, The Netherlands.ORCID 0000-0002-3077-5582

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) 024.003.013Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) 20941Oncode Institute 01ZonMw (Netherlands Organisation for Health Research and Development) 01142052310003
6 · The paper itself

Abstract

Tissue stem cell (TSC)-derived epithelial organoids are typically cultured in Matrigel [T. Sato

Indexed as

Cell Culture Techniques, Three DimensionalEpithelial CellsHydrogelsOrganoidsAnimalsHumansMiceHydrogelsbiomaterialsInvasinorganoidPICstem cells

Identifiers

PMID41091766
PMCPMC12557532

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.