Evidence map›Paper›PMID 41091759›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility.

Rie Iida-Norita, Haruhiko Miyata, Akinori Ninomiya, Chihiro Emori, Maki Kamoshita, Chen Pan, Haoting Wang, Masahito Ikawa

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rie Iida-NoritaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-0104-1974
Haruhiko MiyataDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-4758-5803
Akinori NinomiyaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0000-0001-6133-3835
Chihiro EmoriDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka 565-0871, Japan.
Maki KamoshitaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka 565-0871, Japan.
Chen PanDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka 565-0871, Japan.
Haoting WangDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0009-0000-5176-7170
Masahito IkawaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka 565-0871, Japan.ORCID 0000-0001-9859-6217

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
Gates Foundation INV-001902HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD088412Japan Agency for Medical Research and Development (AMED) JP23jf0126001MEXT | Japan Society for the Promotion of Science (JSPS) JP21H05033MEXT | Japan Society for the Promotion of Science (JSPS) JP22H03214MEXT | Japan Society for the Promotion of Science (JSPS) JP23K18328MEXT | Japan Society for the Promotion of Science (JSPS) JP23K20043MEXT | Japan Society for the Promotion of Science (JSPS) JP25K02773MEXT | JST | Core Research for Evolutional Science and Technology (CREST) JPMJCR21N1MEXT | JST | Fusion Oriented REsearch for disruptive Science and Technology (FOREST) JPMJFR211FNICHD NIH HHS R01 HD088412NIGMS NIH HHS R01 GM129325
6 · The paper itself

Abstract

Sperm motility is essential for male fertility and is tightly controlled by signaling events in the flagellum.

Indexed as

FertilityInfertility, MaleMembrane ProteinsSodium-Hydrogen ExchangersSperm MotilityAdenylyl CyclasesAnimalsCyclic AMPMaleMiceMice, KnockoutSignal TransductionSpermatozoaSperm TailAdenylyl CyclasesCyclic AMPMembrane ProteinsSodium-Hydrogen ExchangerscAMP signalingmale fertilitysodium-proton exchangersperm motilitytherapy for infertility

Identifiers

PMID41091759
PMCPMC12557800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.