Evidence map›Paper›PMID 41091757›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in

Miyuki Suzawa, W Kyle McPherson, Kelly E Dunham, Elizabeth E Van Gorder, Shivani Reddy, Leila A Jamali, Michelle L Bland

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miyuki SuzawaDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908-0875.ORCID 0009-0000-3453-6055
W Kyle McPhersonDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908-0875.ORCID 0009-0008-0796-4300
Kelly E DunhamDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908-0875.ORCID 0000-0002-2605-4440
Elizabeth E Van GorderDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908-0875.ORCID 0000-0002-1213-7579
Shivani ReddyDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908-0875.ORCID 0000-0002-5680-9584
Leila A JamaliDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908-0875.ORCID 0009-0000-3668-9434
Michelle L BlandDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22908-0875.ORCID 0000-0003-0113-1152

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Research Training in Neuroendocrinology and MetabolismT32DK007646 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZHENQI LIU · 1990 to 2026
$4.9M
Signaling mechanisms linking infection, endocrine dysfunction, and growth failureR01DK123433 · NIDDK · UNIVERSITY OF VIRGINIA · PI BLAND, MICHELLE L · 2021 to 2024
$1.6M
Training in the Pharmacological SciencesT32GM148379 · NIGMS · UNIVERSITY OF VIRGINIA · PI Michelle L Bland, Thurl E. Harris · 2023 to 2026
$1.3M
HHS | NIH (NIH) R01DK123433HHS | NIH (NIH) T32DK007646HHS | NIH (NIH) T32GM148379NIDDK NIH HHS R01 DK123433NIDDK NIH HHS T32 DK007646NIGMS NIH HHS T32 GM148379NIH HHS P40 OD018537
6 · The paper itself

Abstract

Nutrient intake drives secretion of insulin and insulin-like peptides that stimulate anabolic metabolism and tissue growth. Eight

Indexed as

Dietary ProteinsDietary SugarsDrosophila melanogasterDrosophila ProteinsInsulinsAnimalsDrosophilaFat BodyHemolymphInsulinInsulin-Like PeptidesLarvaReceptor, InsulinDietary ProteinsDietary SugarsDrosophila ProteinsInsulinInsulin-Like PeptidesInsulinsReceptor, Insulindietary nutrientsDrosophilagrowthinsulin signalingmetabolism

Identifiers

PMID41091757
PMCPMC12557502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.