Evidence map›Paper›PMID 41091675›Full record

ArticlePloS one2025

Return-to-work for people living with long COVID: A scoping review of interventions and recommendations.

Gagan Nagra, Victor E Ezeugwu, Geoff P Bostick, Erin Branton, Liz Dennett, Kevin Drake, Quentin Durand-Moreau, Christine Guptill, Mark Hall, Chester Ho and 5 more

Abstract readScoping Review
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gagan NagraRehabilitation Science Program, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.ORCID https://orcid.org/0009-0009-2687-6848
Victor E EzeugwuDepartment of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
Geoff P BostickDepartment of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
Erin BrantonRehabilitation Science Program, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
Liz DennettGeoffrey and Robyn Sperber Health Sciences Library, University of Alberta, Edmonton, Canada.
Kevin DrakeService Manager, Workers' Compensation Board Alberta Millard Health, Edmonton, Canada.
Quentin Durand-MoreauDivision of Preventive Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton.ORCID https://orcid.org/0000-0003-1168-4201
Christine GuptillSchool of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada.ORCID https://orcid.org/0000-0002-5080-2672
Mark HallDepartment of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
Chester HoDepartment of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada.
Pam HungRehabilitation Science Program, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.ORCID https://orcid.org/0000-0003-2087-0516
Aiza KhanRehabilitation Science Program, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
Grace Y LamDepartment of Medicine, Division of Pulmonary Medicine, University of Alberta, Edmonton.
Behdin Nowrouzi-KiaDepartment of Occupational Science and Occupational Therapy, Temerity Faculty of Medicine, University of Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-5586-4282
Douglas P GrossDepartment of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.ORCID https://orcid.org/0000-0002-2427-6277

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLong COVID is characterized by the presence of new onset or persistent symptoms 3 months after a suspected or confirmed history of SARS-CoV-2 infection. It is a complex and multi-faceted condition that affects people in different ways. Long COVID affects individuals' labour market participation. While some cannot work, others may return to work (RTW) in a limited capacity. Determining what rehabilitation or related strategies are safe and effective for facilitating RTW is necessary.

objectivesTo synthesize evidence on RTW interventions for people living with Long COVID and to identify 'promising' interventions for enhancing work ability and RTW.

methodsWe followed Arksey & O'Malley's methodology and the PRISMA extension for scoping reviews. Five electronic bibliographic databases and grey literature were searched. The literature search included various study designs, such as randomized controlled trials (RCT), quasi-experimental designs, and observational studies as well as clinical practice guidelines (CPGs). Two reviewers conducted screening and data extraction, with disagreements resolved through consensus. Intervention studies were categorized as promising (statistically significant RTW outcomes or ≥ 50% RTW), somewhat promising (20% to < 50% RTW), not promising (non-statistically significant RTW outcomes or < 20% RTW), or uncertain (did not specify proportion of RTW).

resultsTwelve CPGs and nineteen intervention studies were identified. Of the intervention studies, 5 were cohort studies, 3 quasi-experimental studies, 4 observational, 2 interventional, 3 RCTs, and 2 case reports. Promising interventions included multimodal and interdisciplinary work-focused rehabilitation, multidisciplinary inpatient and outpatient rehabilitation, psychoeducation, pacing, and breathing strategies, shifting focus from symptom monitoring to optimizing functional outcomes, enhanced external counterpulsation inflatable pressure to improve blood flow, and constraint-induced cognitive therapy.

conclusionMany uncertainties remain regarding which RTW interventions are effective or the optimal characteristics of these interventions.

Indexed as

Post-Acute COVID-19 SyndromeReturn to WorkHumans

Identifiers

PMID41091675
PMCPMC12527184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.