Evidence map›Paper›PMID 41091600›Full record

ArticleCell reports2025

Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors.

Michael C Tackenberg, Kristina M Heliodoro, Lily C Melink, Yifan Liu, Kun Zhu, Mitchell A Lazar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Reconsidering mammalian circadian organization.Neurobiology of sleep and circadian rhythms · 2026
    Article
  2. Article
  3. medRxiv : the preprint server for health sciences · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael C TackenbergInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Kristina M HeliodoroInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Lily C MelinkInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Yifan LiuInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Kun ZhuInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Mitchell A LazarInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: lazar@pennmedicine.upenn.edu.

Funding

REV-ERB Nuclear Receptors in Circadian Rhythm and MetabolismR01DK045586 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1992 to 2026
$12.0M
Investigating the metabolic effects and de novo establishment of circadian timing differences between brain and liverF32DK132830 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TACKENBERG, MICHAEL · 2022 to 2024
$218k
NIDDK NIH HHS F32 DK132830NIDDK NIH HHS R01 DK045586
6 · The paper itself

Abstract

REV-ERB nuclear receptors are integrated into the molecular circadian clock present in most mammalian cells. Loss of REV-ERBs (REV-ERB DKO) within the suprachiasmatic nucleus (SCN) in vivo leads to a marked shortening of the circadian period, but it remains unclear whether REV-ERB regulation of circadian period is tissue autonomous, if it is conserved across tissues, and how it is established. Here, we show that period shortening in the absence of REV-ERBs is tissue autonomous, is consistent between brain and liver, and is brought about through derepression of clock transcription factors NPAS2 and CLOCK. Thus, in addition to disruption of synchrony with the external environment, our results demonstrate that the circadian impacts of REV-ERB loss also include the alteration of core circadian properties with tissue-specific consequences.

Indexed as

Basic Helix-Loop-Helix ProteinsCircadian RhythmNerve Tissue ProteinsNuclear Receptor Subfamily 1, Group D, Member 1Receptors, Cytoplasmic and NuclearAnimalsBrainCircadian ClocksCLOCK ProteinsLiverMiceMice, Inbred C57BLMice, KnockoutSuprachiasmatic NucleusBasic Helix-Loop-Helix ProteinsCLOCK ProteinsNerve Tissue ProteinsNpas2 protein, mouseNr1d1 protein, mouseNuclear Receptor Subfamily 1, Group D, Member 1Receptors, Cytoplasmic and NuclearCP: MetabolismCP: Neuroscience

Identifiers

PMID41091600
PMCPMC12608050

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.