Evidence map›Paper›PMID 41091551›Full record

SynthesisHuman vaccines & immunotherapeutics2025

Effectiveness and impact of 7 and 13-valent pneumococcal conjugate vaccines in Chinese children: A systematic review and meta-analysis.

Ran Peng, Tao Zhang, Eileen M Dunne, Zhengyun Xu, Anli Sun, Jingyuan Cheng, Junfeng Yang, Genming Zhao

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ran PengSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Tao ZhangSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.ORCID 0000-0002-9029-5708
Eileen M DunneVaccines, Pfizer Vaccines, Collegeville, PA, USA.
Zhengyun XuMedical, Pfizer, Shanghai, China.
Anli SunMedical, Pfizer, Shanghai, China.
Jingyuan ChengShanghai Institute of Infectious Disease and Biosecurity, Shanghai, China.
Junfeng YangMedical, Pfizer, Shanghai, China.
Genming ZhaoSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pneumococcal conjugate vaccines (PCVs) are highly effective against pneumococcal diseases, yet coverage in China remains low. We conducted a systematic review of observational studies published between 2006 and 2024 in mainland China, Hong Kong, and Taiwan to evaluate the effectiveness and impact of PCV7 and PCV13. Twenty-seven studies were identified, of which 17 were included in meta-analyses. PCVs showed strong protection against invasive pneumococcal disease (pooled effectiveness: 88.8%, 95%CI: 80.7-96.8%) and significantly reduced the incidence of community-acquired pneumonia (14.3%, 95%CI: 10.1-18.5%). Vaccine-serotype CAP was reduced by 69.9% (95%CI: 60.0-79.7%), and moderate benefits were observed against severe pneumonia, mortality, and recurrent episodes. Evidence for otitis media remained limited. These findings highlight the substantial health benefits of PCVs in Chinese children and underscore the importance of expanding vaccine utilization to reduce the burden of pneumococcal disease.

Indexed as

Heptavalent Pneumococcal Conjugate VaccinePneumococcal InfectionsPneumococcal VaccinesVaccine EfficacyChildChild, PreschoolChinaCommunity-Acquired InfectionsEast Asian PeopleHumansIncidenceInfantObservational Studies as TopicOtitis MediaPneumonia, PneumococcalStreptococcus pneumoniae13-valent pneumococcal vaccineHeptavalent Pneumococcal Conjugate VaccinePneumococcal VaccinesVaccines, Conjugatecommunity-acquired pneumoniainvasive pneumococcal diseaseMeta-analysispneumococcal conjugate vaccinevaccine effectiveness

Identifiers

PMID41091551
PMCPMC12530490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.