Evidence map›Paper›PMID 41091356›Full record

ArticleJournal of autism and developmental disorders2025

Psychiatric Clinical Presentations in Adolescents and Adults With Autism Spectrum Disorder With and Without Co-Occurring Gender Diversity: A Retrospective Chart Review.

Christina Macenski, Caitlin Ravichandran, Dana Tran, Christopher J McDougle, Robyn P Thom

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Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Christina MacenskiMcLean Hospital, 115 Mill St, Belmont, MA, 02478, USA.
Caitlin RavichandranMcLean Hospital, 115 Mill St, Belmont, MA, 02478, USA.
Dana TranLurie Center for Autism, 1 Maguire Road, Lexington, MA, 02421, USA.
Christopher J McDougleLurie Center for Autism, 1 Maguire Road, Lexington, MA, 02421, USA.
Robyn P ThomLurie Center for Autism, 1 Maguire Road, Lexington, MA, 02421, USA. rthom@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-8026-6970

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePsychiatric presentations and psychopathology in people with co-occurring gender diversity (GD) and autism spectrum disorder (ASD) are not well understood. The aim of this study is to characterize mental health presentations and history (psychiatric diagnoses, psychotropic medication use, history of suicidal ideation and suicide attempts, and psychiatric hospitalization rates) in patients with co-occurring ASD and GD among those seeking psychiatric care at a tertiary care outpatient neurodevelopmental disorders center.

methodsThis retrospective chart review included 125 patients who were divided into three study groups: index patients with co-occurring GD and ASD (n = 25), and age-matched comparison males (n = 50) and females (n = 50) with ASD and without indication of GD in their medical records. All subjects were required to have one initial psychiatric note documented in their electronic medical record (EMR), and their records were reviewed for psychiatric diagnoses, psychotropic medication use, history of suicidal ideation and suicide attempts, and psychiatric hospitalizations.

resultsAll three groups experienced high rates of psychopathology across all characteristics of presentation and history assessed, aside from psychiatric hospitalization which was infrequent across groups. 119/125 (95%) subjects were assigned two or more psychiatric diagnoses in addition to the ASD diagnosis required for study eligibility.

conclusionResults warrant further investigation of the prevalence of psychiatric conditions in GD individuals with ASD.

Indexed as

Autism spectrum disorderGender diversityMental healthPsychiatryPsychopathology

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