ArticleIntensive care medicine experimental2025
Electrochemical skin conductance is associated with peripheral tissue hypoperfusion in septic patients.
Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAutonomic nervous system (ANS) dysfunction contributes to the pathophysiology of sepsis. However, studies using reliable methods for ANS activity monitoring and evaluating its association with outcomes in sepsis patients are scarce. The Sudoscan
methodsThis prospective, observational, single-center study included 97 consecutive adult ICU septic patients without or with shock. Sudoscan
resultsOf the 97 septic patients included, 37% had shock. Mottling was frequent (53%), and mean knee CRT was 3.3 ± 2.5 s. The mean admission Sudoscore was 31.2 ± 21 µS and was significantly higher in patients with peripheral perfusion abnormalities, such as mottling compared to no mottling (35.7 ± 21 vs 28.5 ± 19.5 µS, P = 0.04) and prolonged knee CRT > 5 s compared to CRT < 5 s (44.2 ± 25 vs 29.6 ± 18.6 µS, P = 0.03). Additionally, Sudoscore positively correlated with CRT (P = 0.01, R = 0.27). There was no difference in Sudoscore between patients receiving vasopressors or not, and between patients receiving sedative drugs or not. Longitudinally, the Sudoscore course was significantly lower over the first 72 h in survivors compared to non-survivors (P = 0.04, two-way ANOVA mixed model effect).
conclusionElectrochemical skin conductance measured via Sudoscan
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