Evidence map›Paper›PMID 41091272›Full record

SynthesisClinical oral investigations2025

Premixed calcium silicate-based materials for pulpotomy outcomes in permanent and deciduous teeth: a systematic review and meta-analysis of clinical trials.

Felipe Immich, Wellington Luiz de Oliveira da Rosa, Giampiero Rossi-Fedele, Lucas Peixoto de Araújo, Evandro Piva

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Felipe ImmichSchool of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil.ORCID 0000-0002-2478-4861
Wellington Luiz de Oliveira da RosaDepartment of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, 96015-560, RS, Brazil.ORCID 0000-0001-6992-3127
Giampiero Rossi-FedeleAdelaide Dental School, University of Adelaide, Adelaide, SA, Australia.ORCID 0000-0002-8287-1226
Lucas Peixoto de AraújoSchool of Dentistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2893-1416
Evandro PivaDepartment of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, 96015-560, RS, Brazil. piva@ufpel.edu.br.ORCID 0000-0002-5970-5158

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 315938/2023-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

objectivesPremixed calcium silicate-based cements (PCSCs) offer practical advantages over mineral trioxide aggregate (MTA) and calcium hydroxide (CH), including easier handling, ready-to-use formulation, and rapid setting. This systematic review assessed patient- and clinician-related outcomes of PCSCs compared to MTA and CH for pulpotomies.

methodsA comprehensive search of five databases and grey literature identified 14 clinical trials (eight in permanent and six in deciduous teeth). Risk of bias was evaluated using RoB 2.0, and evidence certainty with GRADE. Meta-analyses of success rates were performed using random-effects models.

resultsSuccess rates ranged from 76.6 to 97.1%, with no significant differences between PCSCs and comparators. MTA showed higher tooth discoloration in permanent teeth. Eight studies were rated as having low risk of bias. Evidence certainty was low for permanent teeth and moderate for deciduous teeth. Further well-designed trials with larger samples and longer follow-ups are needed to strengthen the evidence base.

conclusionPCSCs are efficient as pulpotomy materials in both permanent and deciduous teeth, with comparable or similar success rates and less tooth discoloration compared to MTA in up to 12 months of follow-up. CLINICAL RELEVANCE: PCSCs offer similar pulpotomy success rates to MTA and CH, with easier handling and less tooth discoloration, supporting their clinical use in both pediatric and adult dental care.

Indexed as

Calcium CompoundsDental CementsPulpotomySilicatesTooth, DeciduousAluminum CompoundsCalcium HydroxideClinical Trials as TopicDentition, PermanentDrug CombinationsHumansOxidesTreatment OutcomeAluminum CompoundsCalcium CompoundsCalcium Hydroxidecalcium silicateDental CementsDrug Combinationsmineral trioxide aggregateOxidesSilicatesCalcium silicateEndoSequence root repair materialIRoot BP plusPulp capping and pulpectomy agentsPulpotomy

Identifiers

PMID41091272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.