ReviewDiscover oncology2025
Strategies to reduce intestinal toxicity in neoadjuvant management of locally advanced rectal cancer.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of locally advanced rectal cancer has progressively evolved to improve both survival outcomes and quality of life. Intestinal toxicity is a prevalent side-effect of pelvic radiotherapy affecting most patients. The pursuit of neoadjuvant intensified treatment strategies to enhance response rates or facilitate organ preservation may lead to an increased likelihood of late toxicity, depending on radiation technique and chemotherapy intensity. This narrative review synthesizes current knowledge on radiation-induced intestinal toxicity, refines effective strategies, with an emphasis on studies evaluating techniques to reduce both unintended and intended radiation exposure to the small intestine in locally advanced rectal cancer patients, and highlights their clinical significance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.