ArticleDiscover oncology2025
Heparanase2 inhibits the growth of gallbladder cancer by regulating the VEGF/VEGFR pathway.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Heparanase 2 (Hpa2), a homolog of heparinase, lacks the conventional heparinase activity associated with heparin degradation. However, it exhibits a greater affinity for heparin sulfate (HS) compared to heparinase. In our study, overexpression of Hpa2 significantly inhibited the viability, migration, and invasion of gallbladder cancer cells, both in vivo and in vitro. Moreover, this inhibitory effect of Hpa2 was reversed upon administration of agonists targeting the VEGF/VEGFR pathway. These findings suggest that Hpa2 overexpression may impede the growth of NOZ cells, potentially through modulation of the VEGF/VEGFR signaling pathway.
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