SynthesisClinical oral investigations2025
Effectiveness of treatments for temporomandibular joint osteoarthritis: a systematic review and meta-analysis.
Synthesis in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Extracellular Matrix Remodeling and Glycoprotein Biomarkers Across Osteoarthritis, Rheumatoid Arthritis, and Temporomandibular Disorders: A Systematic Review and Integrative Analysis.International journal of molecular sciences · 2026Pooled it
- Baseline Oral Behaviours in Relation to Follow-Up Temporomandibular Joint Disease Severity After Intra-Articular I-PRF: A Baseline-Adjusted Exploratory Cohort Study.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectivesTo evaluate the effectiveness of minimally invasive interventions (arthrocentesis and intra-articular injections) versus conservative therapies for temporomandibular joint osteoarthritis (TMJ OA).
methodsThis systematic review included randomized controlled and prospective or observational studies involving patients with TMJ OA. A comprehensive search of five databases was conducted up to November 2024. Pain intensity (VAS) and maximum mouth opening (MMO) were analyzed via meta-analysis, with risk of bias assessed using ROB 2 and ROBINS-I tools, and certainty of evidence using GRADE. The significance level adopted for the analysis was set at α = 0.05.
resultsSixteen studies (901 patients) were included. Arthrocentesis, alone or with adjuvants such as PRP, i-PRF, corticosteroids, or NSAIDs, significantly improved pain (MD - 5.50; 95%CI: - 6.61 to - 4.39) and MMO (MD 6.97 mm; 95%CI: 1.96 to 11.98) versus baseline and between groups. Intra-articular hyaluronic acid, with or without glucosamine, showed clinical benefit over time, but its superiority over conservative care was inconsistent. Substantial heterogeneity was observed, mainly in injection-based protocols. GRADE indicated high certainty of evidence for most comparisons, except one (MMO, moderate certainty).
conclusionsMinimally invasive therapies, especially arthrocentesis with biological adjuvants, seems to be effective for TMJ OA management. However, due to heterogeneity and methodological limitations, their superiority over conservative strategies remains uncertain. STATEMENT CLINICAL RELEVANCE: Minimally invasive therapies, particularly arthrocentesis with or without biological agents, may reduce pain and improve jaw function in TMJ OA, offering a potential alternative to conservative treatments over a 3- to 12-month period.
Indexed as
Identifiers
41091224What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.