ArticleAbdominal radiology (New York)2026
Comparison of hepatic PDFF, T2*, and T2 estimates from breath-hold and free-breathing respiratory-gated MRI acquisitions in children and young adults.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Water-T1, PDFF, and T2* mapping of the liver using chemical shift-encoded MOLLI.Abdominal radiology (New York) · 2026Article
- Impact of hepatic steatosis and MOLLI acquisition parameters on liver T1 estimates.Abdominal radiology (New York) · 2026Article
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7 authors.
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Abstract
purposeRespiratory motion during data acquisition may compromise image quality and quantitative accuracy of MRI, particularly in patients with limited breath-holding capability. This study aimed to compare hepatic proton density fat fraction (PDFF), T2*, and T2 estimates of the liver obtained from breath-hold (BH) acquisitions with those from corresponding free-breathing respiratory-gated (RG) MRI acquisitions.
methodsIn this IRB-approved study, healthy controls and patients with liver disease underwent quantitative liver MRI. Hepatic PDFF and T2* were estimated using a confounder-corrected chemical shift-encoded (mDIXON Quant) sequence, and T2 was estimated using a multi-echo Gradient and Spin Echo (mGRASE) sequence with fat suppression, each performed as both BH and RG acquisitions with identical acquisition parameters. Three observers independently drew regions of interest (ROIs) on PDFF, T2*, and T2 maps and agreement between mean values was compared using intraclass correlation coefficients (ICC) and Bland-Altman analysis.
resultsNineteen participants (15.4 ± 5.5 years; 9 males) were evaluated. Scan times were 7 s and 14 s (BH) and 21 ± 6 s and 28 ± 4 s (RG) for mDIXON Quant and mGRASE respectively. Estimated values from BH acquisitions were: PDFF - median 5% (range 1-43%), T2* - mean 27 ms (range 9-41 ms), and T2 - mean 48 ms (range 34-63 ms). RG and BH acquisitions yielded comparable values with biases of -0.33% [-1.42 to 0.76%] for PDFF, -1.58 ms [-9.50 to 6.33 ms] for T2*, and 0.16 ms [-2.43 to 2.12 ms] for T2, and strong correlations (ICC = 0.99 [0.99, 0.99], 0.85 [0.66, 0.94], and 0.99 [0.97, 0.99] for PDFF, T2*, and T2).
conclusionRG acquisitions provide hepatic PDFF, T2*, and T2 estimates comparable to BH acquisitions without substantial time penalty and are a viable alternative for patients with limited breath-holding ability.
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