Evidence map›Paper›PMID 41091170›Full record

ArticlePsychopharmacology2026

Nicotine reward in the conditioned place preference test across a panel of male inbred mice and F1 crosses: genetic influence and correlation with variation in nicotine antinociception.

Belle Buzzi, Shakir D AlSharari, Julian Vaughn, Erin Kalck, Walker D Rogers, Amber Baldwin, Gina M Fernandez, Michael F Miles, M Imad Damaj

Abstract read
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Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Belle Buzzi *Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 1217 E Marshall St, 23298, Richmond, VA, USA.
Shakir D AlSharari *Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Julian VaughnDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 1217 E Marshall St, 23298, Richmond, VA, USA.
Erin KalckDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 1217 E Marshall St, 23298, Richmond, VA, USA.
Walker D RogersDepartment of Human and Molecular Genetics, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 E Marshall St, 23298, Richmond, VA, USA.
Amber BaldwinNeuroscience Program, Christopher Newport University, 1 Avenue of the Arts, 23606, Newport News, VA, USA.
Gina M FernandezDepartment of Psychology, Christopher Newport University, 1 Avenue of the Arts, 23606, Newport News, VA, USA.
Michael F MilesDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 1217 E Marshall St, 23298, Richmond, VA, USA.
M Imad DamajDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, 1217 E Marshall St, 23298, Richmond, VA, USA. m.damaj@vcuhealth.org.

Funding

Genes and molecular pathways in nicotine dependence and withdrawalR01DA032246 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DAMAJ, M. IMAD, MILES, MICHAEL F · 2013 to 2017
$1.7M
NIDA NIH HHS R01 DA032246
6 · The paper itself

Abstract

backgroundInbred mouse strains provide valuable genomic tools to investigate substances of abuse, including nicotine, and the individual vulnerability of smoking-related behaviors. This study was designed to explore diverse genetic influences in nicotine-mediated reward.

methodsPotency (ED

resultsNicotine induced CPP in most strains with an inverted U-shape dose-response curve. However, DBA/2J, and B6D2F1 did not show preference in any dose tested. Separately, CBA/J, DBA/2J, and B6D2F1 all formed an aversion at the highest dose of nicotine tested. The rank order for sensitivity to nicotine-induced CPP was A/J = 129/SvEv > B6129F1 > B6CBAF1 = C57BL/6J > C3H/ HeJ > BALB/ByJ > CBA/J > DBA/2J = B6D2F1. For the 0.25 and 0.5 mg/kg nicotine doses, there was a strong pattern of genetic heritability. Across 6 inbred strains, there was a significant, positive correlation between ED

conclusionOverall, genotypes had marked effects on both CPP and antinociception. These data strongly suggest an influence of genetic factors in the rewarding and antinociceptive effects of nicotine, which may influence an individual's vulnerability to cigarette smoking.

Indexed as

Conditioning, PsychologicalNicotineNicotinic AgonistsRewardAnimalsCrosses, GeneticDose-Response Relationship, DrugMaleMiceMice, Inbred C57BLMice, Inbred DBAMice, Inbred StrainsSpecies SpecificityNicotineNicotinic AgonistsConditioned place preferenceGeneticsInbredMouseNicotinePainPreferenceRewardStrain

Identifiers

PMID41091170

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Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.