Evidence map›Paper›PMID 41091058›Full record

ArticleTurkish journal of haematology : official journal of Turkish Society of Haematology2026

Expression of Immune Checkpoints

Komal Khan, Umaima Khan, Asma Shah, Syed Muhammad Ikram Shah, Yousaf Khan, Muhammad Tariq Masood Khan, Gulab Fatima Rani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Komal KhanKhyber Medical University, Institute of Pathology and Diagnostic Medicine, Department of Hematology, Peshawar, Pakistan
Umaima KhanKhyber Medical University, Institute of Pathology and Diagnostic Medicine, Department of Hematology, Peshawar, Pakistan
Asma ShahKhyber Medical University, Institute of Pathology and Diagnostic Medicine, Department of Hematology, Peshawar, Pakistan
Syed Muhammad Ikram ShahKhyber Medical University, Institute of Pathology and Diagnostic Medicine, Department of Hematology, Peshawar, Pakistan
Yousaf KhanKhyber Medical University, Institute of Pathology and Diagnostic Medicine, Department of Hematology, Peshawar, Pakistan
Muhammad Tariq Masood KhanPeshawar Institute of Medical Sciences, Department of Hematology, Peshawar, Pakistan
Gulab Fatima RaniKhyber Medical University, Institute of Pathology and Diagnostic Medicine, Department of Hematology, Peshawar, PakistanORCID 0000-0002-2209-1893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Beta-thalassemia is an inherited hemoglobin disorder caused by mutations in the Materials and Methods: Gene expression levels of Results: This study revealed increased expression of Conclusion: The findings of this study are suggestive of alterations in immune regulation in beta-thalassemia that could be attributed to thalassemia itself, repeated exposure to blood products, recurrent infections, and the use of immunomodulatory drugs.

Indexed as

Antigens, CDbeta-ThalassemiaCTLA-4 AntigenFetal HemoglobinHepatitis A Virus Cellular Receptor 2Immune Checkpoint ProteinsProgrammed Cell Death 1 ReceptorAdolescentAdultBlood TransfusionChildFemaleHumansLymphocyte Activation Gene 3 ProteinMaleYoung AdultAntigens, CDCTLA-4 AntigenCTLA4 protein, humanFetal HemoglobinHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Immune Checkpoint ProteinsLag3 protein, humanLymphocyte Activation Gene 3 ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorBeta-thalassemiaHbF augmentation therapyHydroxyureaImmune checkpointsThalidomide

Identifiers

PMID41091058
PMCPMC12922553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.