Evidence map›Paper›PMID 41090954›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Facile Access to Chelating CAArC-Phosphine (CAArCPhos) Palladium Complexes.

K Georg Leistikow, Alexander Wingelstern, Philipp Rohrmann, Jonas F Wunsch, Jan Werst, Margit Brückner, Frank Rominger, Matthias Rudolph, A Stephen K Hashmi

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Facile Access to Chelating CAArC-Phosphine (CAArCPhos) Palladium Complexes.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

K Georg LeistikowOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Alexander WingelsternOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Philipp RohrmannOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Jonas F WunschOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Jan WerstOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Margit BrücknerOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Frank RomingerOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Matthias RudolphOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
A Stephen K HashmiOrganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-6720-8602

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this article, we present a synthetic route to 4-(diphenyl-phosphino) isoindolium salts based on a new protecting group strategy. Key to success is the use of hemi-aminal methyl ether precursors, which serve as base-stable iminium salt equivalents that enable halogen-metal exchange and subsequent functionalization. After removal of the protecting group, the catalytically active palladium(II) complexes are formed of phosphine isoindolium salts by a CMD-like metalation process, producing the first examples of chelating cyclic amino(aryl) carbene complexes. Calculations on the mechanism support an acetate-assisted intramolecular palladation of the cyclic amino(aryl) carbene-phosphine (CAArCPhos) ligand enabled by the phosphine directing group through a six-membered transition state.

Indexed as

CAArCsC–H activationChelating carbene ligandsDirecting groupsPalladium

Identifiers

PMID41090954
PMCPMC12643342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.