Evidence map›Paper›PMID 41090914›Full record

ArticleMicrobiology spectrum2025

Epidemiology of respiratory syncytial virus in young, hospitalized children in Jordan: a prospective viral surveillance study.

Justin Z Amarin, Haya Hayek, Olla Hamdan, Yasmeen Z Qwaider, Tala Khraise, Ahmad Khader, Qusai Odeh, Rami Salim, Hadeel Shalabi, Ahmad Alhajajra and 8 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Justin Z Amarin *Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-4484-1077
Haya Hayek *Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0087-4392
Olla HamdanDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-3703-5536
Yasmeen Z QwaiderDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Tala KhraiseDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ahmad KhaderDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Qusai OdehDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Rami SalimDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Hadeel ShalabiDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ahmad AlhajajraDepartment of Pediatrics, Al-Bashir Hospital, Amman, Jordan.
Yousef KhaderDepartment of Public Health and Community Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Basim Al-ZoubiDepartment of Pediatrics, Al-Bashir Hospital, Amman, Jordan.
Najwa Khuri-BulosDepartment of Pediatrics, School of Medicine, The University of Jordan, Amman, Jordan.
Andrew J SpiekerDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Leigh M HowardDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-4301-7235
James D ChappellDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Natasha B HalasaDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jordan Viral Surveillance Studies Group

Funding

Merck & Co.
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a leading cause of hospitalization in young children. Understanding RSV burden and seasonality is crucial for implementing effective preventive strategies, especially in the wake of disruptions related to the coronavirus disease 2019 (COVID-19) pandemic. We aimed to determine RSV burden and seasonality among young children hospitalized in Jordan. We conducted a prospective viral surveillance study at Al-Bashir Hospital (1 November 2023 to 4 April 2024). Children <5 years old hospitalized with fever or respiratory symptoms were eligible. Nasal (and optional throat) swabs were collected and tested for common respiratory viruses using real-time polymerase chain reaction. We compared characteristics and outcomes of hospitalizations by RSV detection status and assessed RSV seasonality. Of 2,610 children, RSV was detected in 713 (27.3%), making it the second most common virus overall and the most common in children <2 years old ( IMPORTANCE: This study confirms the persistent and significant burden of respiratory syncytial virus (RSV) among young, hospitalized children in Jordan. Crucially, our data reveal the normalization of RSV circulation patterns in 2024 following disruptions related to the coronavirus disease 2019 pandemic. This finding has important implications for optimizing the timing of preventive interventions, such as monoclonal antibodies and maternal vaccination, particularly in a resource-limited setting where they are costly and limited in availability. By providing these contemporary surveillance data from the Eastern Mediterranean-where sentinel surveillance platforms are lacking-this work has the potential to inform public health strategies directly and emphasizes the critical need for sustained monitoring to guide effective RSV prevention and control efforts.

Indexed as

Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsChild, PreschoolCOVID-19Epidemiological MonitoringFemaleHospitalizationHumansInfantInfant, NewbornJordanMaleProspective StudiesSARS-CoV-2SeasonschildhospitalizationinfantJordanpreschoolrespiratory syncytial virus infections

Identifiers

PMID41090914
PMCPMC12584765

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.