Evidence map›Paper›PMID 41090778›Full record

ArticleCells2025

IDO-Mediated Immune and Metabolic Dysregulation in Schwann Cells Exposed to

Atta Ur Rahman, Raíssa Couto Santana, Mylena Masseno de Pinho Pereira, Claudia Luciana Dos Santos Moura, Débora Santos da Silva, Otto Castro Araujo, Thyago Leal-Calvo, Isabela Espasandin, Tatiana Pereira da Silva, Euzenir Nunes Sarno and 6 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Atta Ur RahmanLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Raíssa Couto SantanaLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.ORCID 0000-0001-5883-3783
Mylena Masseno de Pinho PereiraLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Claudia Luciana Dos Santos MouraLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Débora Santos da SilvaCellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Otto Castro AraujoCellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Thyago Leal-CalvoLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.ORCID 0000-0001-9520-4791
Isabela EspasandinLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.ORCID 0009-0005-4251-9550
Tatiana Pereira da SilvaLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Euzenir Nunes SarnoLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Bruno Jorge de Andrade SilvaLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Rubem Sadok Figueiredo Menna-BarretoCellular Biology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.ORCID 0000-0002-1352-0641
Márcia Maria JardimLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.
Cristiana Santos de MacedoCellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.ORCID 0000-0002-5637-9756
Flávio Alves LaraCellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.ORCID 0000-0002-2717-6597
Roberta Olmo PinheiroLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-361, Brazil.ORCID 0000-0001-8471-4227

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.176/2021Fundação Oswaldo Cruz 921301630878188National Council for Scientific and Technological Development 303834/2017-0National Council for Scientific and Technological Development 3128021/2020-0
6 · The paper itself

Abstract

Leprosy is a chronic infectious disease that targets the peripheral nervous system, leading to peripheral neuropathy.

Indexed as

Indoleamine-Pyrrole 2,3,-DioxygenaseLeprosyMycobacterium lepraeSchwann CellsAnimalsCell SurvivalMembrane Potential, MitochondrialMitochondriaRatsTryptophanIndoleamine-Pyrrole 2,3,-DioxygenaseTryptophanIndoleamine 2,3 Dioxygenase (IDO)kynurenine pathwayMycobacterium lepraeSchwann cells

Identifiers

PMID41090778
PMCPMC12524192

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.