In one paragraphArticle in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Ranan PhookanDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0009-0005-0625-2449 Jordan E MorningstarDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.
Brian LoizziDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.
Antonia Van KampenCardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-4412-6337 Cortney GensemerDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0002-8492-3536 Maja-Theresa DieterlenUniversity Department of Cardiac Surgery, Leipzig Heart Center, Struempellstrasse 39, 04289 Leipzig, Germany.
Ricardo SpampinatoUniversity Department of Cardiac Surgery, Leipzig Heart Center, Struempellstrasse 39, 04289 Leipzig, Germany.
Louis PetitjeanPharmaNest Inc., Princeton, NJ 08540, USA.
Taylor PetrucciDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0003-1524-5804 Roman FennerDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.
Jake GrinerDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0001-6041-0157 Kathryn ByerlyDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.
Robert A LevineCardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-9484-8218 Michael A BorgerUniversity Department of Cardiac Surgery, Leipzig Heart Center, Struempellstrasse 39, 04289 Leipzig, Germany.ORCID 0000-0003-1046-1364 Russell A NorrisDepartment of Regenerative Medicine and Cell Biology, College of Medicine, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0001-8462-5726 Funding
Targeted Nano-therapeutics for Neural RegenerationP20GM103444 · NIGMS · CLEMSON UNIVERSITY · PI MEI, YING · 2012 to 2018
$14.9MImproving Mitral Compensation In Ischemic RegurgitationR01HL141917 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AIKAWA, ELENA, BISCHOFF, JOYCE E. · 2018 to 2021
$5.6MMechanism of Myocardial Fibrosis Induced by Mitral Valve ProlapseR01HL173930 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JUDY W HUNG, Serguei MELNITCHOUK · 2024 to 2026
$5.4MCilia and Valvular Heart DiseaseR01HL131546 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NORRIS, RUSSELL · 2016 to 2025
$4.4MEXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR018823 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND, JOHN R · 2003 to 2003
$2.9MTreating Ventricle and Valve: New Synergies for Ischemic LV Remodeling with MRR01HL128099 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AKAR, FADI GABRIEL, LEVINE, ROBERT A · 2016 to 2019
$2.8MDzip1 and Mitral Valve ProlapseR01HL149696 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NORRIS, RUSSELL · 2020 to 2023
$2.0MDzip1 and Mitral Valve ProlapseR56HL149696 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NORRIS, RUSSELL · 2025 to 2025
$678kMechanisms of Left Ventricular Fibrosis in Mitral Valve ProlapseF31HL167482 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MORNINGSTAR, JORDAN E. · 2023 to 2024
$55kAHA, NIH TPA963783, TPA34850095, 905880, HL128099 , HL141917 , C06 RR018823, GM103444, HL149696, HL131546, HL173930, F31HL167482NCRR NIH HHS C06 RR018823NHLBI NIH HHS F31 HL167482NHLBI NIH HHS R01 HL128099NHLBI NIH HHS R01 HL131546NHLBI NIH HHS R01 HL141917NHLBI NIH HHS R01 HL149696NHLBI NIH HHS R01 HL173930NHLBI NIH HHS R56 HL149696NIGMS NIH HHS P20 GM103444
6 · The paper itselfAbstract
Recent evidence demonstrates that mitral valve prolapse (MVP) increases mechanical stress on the subvalvular apparatus and is linked to regional myocardial fibrosis and life-threatening ventricular arrhythmias. However, current surgical guidelines do not account for the extent of myocardial fibrosis or the severity of leaflet involvement, both key features of arrhythmogenic MVP. To address this gap, we conducted histopathological analysis of endomyocardial biopsies from patients with MVP and regionalized myocardial fibrosis (n = 6) who underwent mitral valve repair. Using digital pathology-based quantitative image analysis (QIA), we found that fibrosis in peri-papillary biopsies exhibited a significantly higher Morphometric Composite Score compared with remote biopsies (5.68 ± 0.69 vs. 3.71 ± 0.49,
Indexed as
CollagenMitral Valve ProlapseAgedBiopsyFemaleFibrosisHumansMaleMiddle AgedMyocardiumCollagencardiac fibrosiscollagendigital pathologymechanoregulationmitral valve prolapse
Identifiers
PMID41090764
PMCPMC12523760
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