Evidence map›Paper›PMID 41090761›Full record

ArticleCells2025

Genomic Analysis Defines Increased Circulating, Leukemia-Induced Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis.

Ting Zhang, Atsuko Matsunaga, Xiaocui Lu, Hui Fang, Nandini Chatterjee, Ahmad Alimadadi, Stephanie F Mori, Xuexiu Fang, Gavin Wang, Huidong Shi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ting ZhangGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.ORCID 0000-0002-0616-5565
Atsuko MatsunagaGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.
Xiaocui LuGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.
Hui FangGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.
Nandini ChatterjeeLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Ahmad AlimadadiLa Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-7888-5019
Stephanie F MoriGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.
Xuexiu FangGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.
Gavin WangDepartment of Biology and Psychology, University of Georgia, Athens, GA 30602, USA.
Huidong ShiGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.ORCID 0000-0003-1137-3390
Litao ZhangDepartment of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China.
Catherine C HedrickImmunology Center of Georgia, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.
Bo ChengDepartment of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.ORCID 0000-0003-1916-0410
Tianxiang HuGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.ORCID 0000-0002-5127-9211
John K CowellGeorgia Cancer Center, 1410 Laney Walker Blvd., Augusta, GA 30912, USA.

Funding

NCI NIH HHS CA076167
6 · The paper itself

Abstract

The development of FGFR1-driven stem cell leukemia and lymphoma syndrome (SCLL) in mouse models is accompanied by an increase in highly heterogenous myeloid derived suppressor cells (MDSCs), which promote immune evasion. To dissect this heterogeneity, we used a combination of CyTOF and scRNA-Seq to define the phenotypes and genotypes of these MDSCs. CyTOF demonstrated increased levels of circulating macrophages in the peripheral blood of leukemic mice, and flow cytometry demonstrated that these macrophages were derived from Ly6C

Indexed as

CarcinogenesisGenomicsLeukemiaMacrophagesReceptor, Fibroblast Growth Factor, Type 1AnimalsDisease Models, AnimalMiceMice, Inbred C57BLMonocytesMyeloid-Derived Suppressor CellsFgfr1 protein, mouseReceptor, Fibroblast Growth Factor, Type 1CyTOFFGFR1 leukemogenesisimmune suppressionmacrophagesmonocytesscRNA-Seq

Identifiers

PMID41090761
PMCPMC12523281

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.