Evidence map›Paper›PMID 41090757›Full record

ArticleCells2025

Unique and Conserved Endoplasmic Reticulum Stress Responses in Neuroendocrine Cells.

Karina Rodrigues-Dos-Santos, Gitanjali Roy, Anna Geisinger, Sahiti Somalraju, Travis S Johnson, Michael A Kalwat

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Karina Rodrigues-Dos-SantosIndiana Biosciences Research Institute, Indianapolis, IN 46202, USA.ORCID 0000-0002-3012-7171
Gitanjali RoyIndiana Biosciences Research Institute, Indianapolis, IN 46202, USA.ORCID 0000-0002-9622-0184
Anna GeisingerIndiana Biosciences Research Institute, Indianapolis, IN 46202, USA.ORCID 0009-0001-7194-1321
Sahiti SomalrajuIndiana Biosciences Research Institute, Indianapolis, IN 46202, USA.
Travis S JohnsonIndiana Biosciences Research Institute, Indianapolis, IN 46202, USA.ORCID 0000-0002-4628-2256
Michael A KalwatIndiana Biosciences Research Institute, Indianapolis, IN 46202, USA.ORCID 0000-0002-8349-9470

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
DMS/NIGMS 1: Topological Study on Histological Images and Spatial TranscriptomicsR01GM148970 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI CHEN, CHAO, JOHNSON, TRAVIS STEELE · 2022 to 2024
$682k
A deep-transfer-learning framework to transfer clinical information to single cells and spatial locations in cancer tissuesR21CA264339 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI JOHNSON, TRAVIS STEELE, ZHANG, JIE · 2022 to 2023
$394k
AnalytixIN N/AIndiana University Grand Challenges Precision Health Initiative N/ANCI NIH HHS 1R21CA264339NCI NIH HHS R21 CA264339NIDDK NIH HHS DK097512NIDDK NIH HHS P30 DK097512NIGMS NIH HHS 1R01GM148970NIGMS NIH HHS R01 GM148970
6 · The paper itself

Abstract

Endocrine cells are dedicated to the production and processing of hormones, from peptides to small molecules, to regulate key physiological processes, including glucose homeostasis and metabolism. Because of this relatively high productivity, endocrine cells must handle a variety of stresses from oxidative stress to the unfolded protein response of the endoplasmic reticulum (UPR

Indexed as

Endoplasmic Reticulum StressNeuroendocrine CellsAnimalsCell LineHumansMiceThapsigarginUnfolded Protein ResponseThapsigargincomputational biologyendocrinologyER stresshormone secretion

Identifiers

PMID41090757
PMCPMC12524277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.