Evidence map›Paper›PMID 41090730›Full record

ReviewCells2025

Heat Shock Proteins in Gastrointestinal and Lung Neuroendocrine Neoplasm: Diagnostic and Therapeutic Perspectives.

Jacek Kabut, Jakub Sokołowski, Wiktoria Żelazna, Mateusz Stępień, Marta Strauchman, Natalia Jaworska, Anita Gorzelak-Magiera, Jakub Wnuk, Iwona Gisterek-Grocholska

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacek KabutDepartment of Oncology and Radiotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.ORCID 0000-0002-0873-4952
Jakub SokołowskiStudent Scientific Club at the Department and Clinic of Oncology and Radiotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.ORCID 0009-0008-7031-5311
Wiktoria ŻelaznaStudent Scientific Club at the Department and Clinic of Oncology and Radiotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.ORCID 0009-0001-8185-4846
Mateusz StępieńStudent Scientific Club at the Department and Clinic of Oncology and Radiotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.ORCID 0009-0000-7313-0437
Marta StrauchmanStudent Scientific Club at the Department and Clinic of Oncology and Radiotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.
Natalia JaworskaStudent Scientific Club at the Department and Clinic of Oncology and Radiotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.
Anita Gorzelak-MagieraDepartment of Oncology and Radiotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.ORCID 0000-0003-4183-4522
Jakub WnukDepartment of Oncology and Radiotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.ORCID 0000-0002-7915-6563
Iwona Gisterek-GrocholskaDepartment of Oncology and Radiotherapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-615 Katowice, Poland.ORCID 0000-0002-6320-0224

Funding

Department of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland. Department of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland.
6 · The paper itself

Abstract

Neuroendocrine tumors (NETs) are a diverse group of rare but clinically important neoplasms with increasing incidence and high biological heterogeneity. Heat shock proteins (HSPs) play a key role in the cellular response to stress, participating in the maintenance of proteome homeostasis and in the regulation of tumorigenesis processes such as proliferation, migration, apoptosis and development of resistance to therapy. This review analyzes the importance of HSPs in the diagnosis, prognosis and therapy of neuroendocrine tumors, as potential prognostic markers and targets of molecularly targeted therapy. The possibility of using HSP activity modulation to increase the efficacy of treatment, especially in cases refractory to standard therapeutic regimens, is emphasized. Due to the increasing clinical importance of NETs and limited therapeutic options in advanced forms, further exploration of the role of HSPs as biomarkers and therapeutic targets in this group of tumors is necessary.

Indexed as

Gastrointestinal NeoplasmsHeat-Shock ProteinsLung NeoplasmsNeuroendocrine TumorsAnimalsBiomarkers, TumorHumansPrognosisBiomarkers, TumorHeat-Shock ProteinsbiomarkersGastroenteropancreatic Neuroendocrine Tumors (GEP-NET)Heat Shock Proteins (HSP)Neuroendocrine Tumors (NET)Pancreatic Neuroendocrine Tumors (PanNET)targeted therapy

Identifiers

PMID41090730
PMCPMC12523940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.