Prolonged Heat-Treated Mesenchymal Precursor Cells Induce Positive Outcomes Following Transplantation in Cervical Spinal Cord Injury.

Seok Voon White, Yee Hang Ethan Ma, Christine D Plant, Alan R Harvey, Giles W Plant

Abstract read

In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seok Voon WhiteDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Yee Hang Ethan MaDepartment of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0007-0537-8896

Christine D PlantDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA 94305, USA.

Alan R HarveySchool of Human Sciences, University of Western Australia, Crawley, WA 6009, Australia.

Giles W PlantDepartment of Neurosurgery, School of Medicine, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7366-652X

Funding

Stanford University SINTNThe Ohio State University 125100

6 · The paper itself

Abstract

Cellular transplantation therapies have been extensively used in experimental spinal cord injury research. However, there is no consensus as to what the most effective cellular controls for the therapeutic cell of interest are. For this reason, we examined whether dead cells obtained through prolonged heat treatment can act as an appropriate cellular control for intravenously injected Sca-1+ mesenchymal precursor cells (MPCs) in C5 unilateral contusion cervical spinal cord injury. This was tested in single intravenous MPC injection alone or intravenous MPC plus intraspinal neural stem cell (NSC) combinatory transplantation studies. MPCs were isolated from the compact bone of FVB mice, while NSCs were isolated from the subventricular zone of luciferase-GFP transgenic FVB mice. Dead MPCs were obtained by heating at 72 °C for at least 12 h. In the MPC only transplant study, injured mice received an injection of 1 × 10

Indexed as

Cervical CordHot TemperatureMesenchymal Stem CellsMesenchymal Stem Cell TransplantationSpinal Cord InjuriesAnimalsFemaleMiceMice, TransgenicNeural Stem Cellscervical spinal cord injurydead cellsintravenous transplantationmesenchymal precursor cellsneural stem cells

Identifiers

PMID41090716

DOI10.3390/cells14191488

PMCPMC12523676

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.