Evidence map›Paper›PMID 41090715›Full record

ArticleCells2025

Reactivation of Human X-Linked Gene and Stable X-Chromosome Inactivation Observed in Generation and Differentiation of iPSCs from a Female Patient with HNRNPH2 Mutation.

Guibin Chen, Alexander Rodriguez-Lopez, Darawalee Wangsa, Richa Madan Lomash, Xiuli Huang, Catherine Z Chen, Rodney A Bowling, Neda Ghousifam, Courtney J Banks, Kerstin A Hurd and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Novel advanced patient-derivedFrontiers in neurology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guibin ChenNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20892, USA.
Alexander Rodriguez-LopezNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20892, USA.
Darawalee WangsaNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20892, USA.
Richa Madan LomashNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20892, USA.
Xiuli HuangNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20892, USA.
Catherine Z ChenNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20892, USA.ORCID 0000-0002-6900-6553
Rodney A BowlingTo Cure a Rose Foundation, Building 4000, 6101 Highland Campus Dr #2250, Austin, TX 78752, USA.ORCID 0009-0001-1480-403X
Neda GhousifamTo Cure a Rose Foundation, Building 4000, 6101 Highland Campus Dr #2250, Austin, TX 78752, USA.
Courtney J BanksTo Cure a Rose Foundation, Building 4000, 6101 Highland Campus Dr #2250, Austin, TX 78752, USA.ORCID 0000-0002-7079-506X
Kerstin A HurdNational Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Jizhong ZouNational Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0003-1021-0549
Wei ZhengNational Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20892, USA.ORCID 0000-0003-1034-0757

Funding

NHLBI iPSC Core FacilityZICHL006145 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZOU, JIZHONG · 2012 to 2025
$23.3M
Intramural NIH HHS ZIC HL006145Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health TR000018
6 · The paper itself

Abstract

X chromosome inactivation (XCI) is a fundamental epigenetic process that balances X-linked gene expression between females and males by silencing one X chromosome in female cells. Variability or skewing of XCI can influence the clinical presentation of X-linked disorders. Bain type X-linked intellectual disability syndrome (MRXSB), caused by mutations in the X-linked

Indexed as

Cell DifferentiationGenes, X-LinkedInduced Pluripotent Stem CellsMutationX Chromosome InactivationCellular ReprogrammingFemaleFibroblastsHumansBain type X-linked intellectual disability syndromeHNRNPH2iPSCX chromosome inactivation

Identifiers

PMID41090715
PMCPMC12523473

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.