Evidence map›Paper›PMID 41090674›Full record

ReviewMolecular pain

Viral vector-mediated interleukin 10 for gene therapy on chronic pain.

Megumi Kanao-Kanda, Hirotsugu Kanda, Shue Liu, Tomoyuki Kawamata, Keith A Candiotti, Shuanglin Hao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Megumi Kanao-KandaDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL, USA.
Hirotsugu KandaDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL, USA.
Shue LiuDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL, USA.
Tomoyuki KawamataDepartment of Anesthesiology, Wakayama Medical University, Wakayama, Japan.
Keith A CandiottiDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL, USA.
Shuanglin HaoDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0003-2435-1473

Funding

Role of Gut Microbiome in HIV/Opioid Induced Peripheral NeuropathyR01DA047089 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HAO, SHUANGLIN, RAMAKRISHNAN, SUNDARAM · 2018 to 2022
$2.3M
A new pathway of spinal neurons in neuropathic pain induced by HIV with opioidR01DA047157 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HAO, SHUANGLIN · 2018 to 2022
$2.1M
Neuropathic mechanisms and gene therapy on opioid dependenceR01DA034749 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HAO, SHUANGLIN · 2014 to 2018
$1.7M
HIV and NRTI's-induced painful pathogenic mechanisms and gene therapyR01NS066792 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAO, SHUANGLIN · 2010 to 2014
$1.6M
BLRD VA I01 BX005114NIDA NIH HHS R01 DA034749NIDA NIH HHS R01 DA047089NIDA NIH HHS R01 DA047157NINDS NIH HHS R01 NS066792
6 · The paper itself

Abstract

Immunomodulatory molecules play a crucial role in the establishment and maintenance of chronic pain. Among these, anti-inflammatory interleukin-10 (IL-10) has emerged as one of therapeutic options to ameliorate pain state. Some components reduced pain through stimulating endogenous IL-10. However, IL-10 has a short half-life, which limits its long-term treatment of chronic pain. Gene therapy targeting

Indexed as

Chronic PainGenetic TherapyGenetic VectorsInterleukin-10AnimalsHumansInterleukin-10chronic paingene therapyIL-10Neuroimmuneviral vectors

Identifiers

PMID41090674
PMCPMC12665025

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.