ArticleActa obstetricia et gynecologica Scandinavica2025
Umbilical venous blood flow and its association with placental pathology in pregnancies complicated by gestational diabetes mellitus.
Article in Acta obstetricia et gynecologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Placental pathology in gestational diabetes mellitus: Associations with neonatal outcomes and postpartum dysglycemia.Acta obstetricia et gynecologica Scandinavica · 2026Observational
- The Natural History of Prediabetes and Cardiovascular Disease in the Pediatric Population.Biomedicines · 2026Review
- Umbilical venous blood flow and its association with placental pathology in pregnancies complicated by gestational diabetes mellitus.Acta obstetricia et gynecologica Scandinavica · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionUmbilical venous blood flow (UV-Q) reflects fetoplacental circulation and contributes to an understanding of fetal physiology. It may also serve as a basis for developing new diagnostic tools to assess fetal wellbeing. This study aimed to investigate UV-Q patterns in pregnancies complicated by gestational diabetes mellitus (GDM) and to examine the associations between absolute and fetal weight-normalized UV-Q and placental size and histologic features. MATERIAL AND
methodsThis prospective study was conducted at a university hospital in Bangkok, Thailand, between December 2021 and May 2024. A total of 200 singleton pregnancies complicated by GDM underwent ultrasound assessment between 35 and 36 weeks of gestation. Measurements included estimated fetal weight, umbilical vein diameter, and Doppler-derived flow velocity. Absolute and normalized UV-Q values were calculated and categorized into three groups: <10th, 10th-90th (reference), and >90th percentiles. After delivery, placental morphometry (weight, diameter, circumference, and volume) and histologic features-including maternal and fetal vascular malperfusion, delayed villous maturation (DVM), and chorangiosis-were evaluated. Associations between UV-Q and placental size were assessed using one-way analysis of covariance, adjusting for parity, insulin use, gestational age at delivery, birthweight, and infant sex. These covariates were also included in the multivariable logistic regression models to examine associations between UV-Q and histologic findings.
resultsHigher absolute UV-Q was significantly associated with greater placental weight, diameter, circumference, and volume (p = 0.018-0.049). Additionally, in multivariable analysis, pregnancies with absolute UV-Q >90th percentile had a significantly increased risk of DVM (adjusted odds ratio 2.75, 95% confidence interval 1.02-7.86). In contrast, normalized UV-Q showed no significant associations with placental morphometric features or DVM. Furthermore, neither absolute nor normalized UV-Q was significantly associated with other histologic placental abnormalities, including maternal or fetal vascular malperfusion or chorangiosis.
conclusionsIn pregnancies complicated by GDM, elevated absolute UV-Q was associated with increased placental size and a higher risk of DVM. These findings suggest that absolute UV-Q may serve as a noninvasive indicator of placental structural adaptation and function in diabetic pregnancies. Further research is needed to clarify the clinical significance and underlying mechanisms of these associations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.