ArticleInternational journal of fertility & sterility2025
Application of Autologous Platelet-Rich Plasma-Supplemented Medium Promotes
Article in International journal of fertility & sterility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oocyte Materials and Methods: In this experimental research, a total of 200 immature oocytes at the germinal vesicle (GV) stage with normal morphology were collected from 76 women who participated in the intracytoplasmic sperm injection (ICSI) procedure. Immature oocytes were randomly distributed into the following two groups: i. The control group, which was cultured in IVM medium for 48 hours and ii. The treatment group, which was incubated in IVM medium supplemented with autologous PRP (5%) for 48 hours at 37°C. Results: Our results showed that the percentage of GV oocytes that progressed into the metaphase II (MII) phase was significantly (P<0.05) increased in the PRP group (34%), as compared to the control group (19%). Moreover, schmorl staining revealed that the number of mature oocytes with refractile bodies (RBs, >5 μm) diminished in the PRP group compared with the control group. However, the differences failed to reach statistical significance. Conclusion: Taken together, our finding demonstrated that adding autologous PRP to the conventional IVM medium increased the meiotic potential of human immature oocytes, probably due to the present of growth factors. This study indicates that PRP may be a beneficial supplement for improving IVM medium.
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