ArticleInternational journal of fertility & sterility2025
Assessing The Effectiveness of Growth Hormone Releasing Protein-6 in Improving Human Oocyte Maturation and Meiotic Progression in
Article in International journal of fertility & sterility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.International journal of molecular sciences · 2025Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The success rate of Materials and Methods: In this experimental study, a total of 240 human germinal vesicle (GV) oocytes were collected and cultured in varying concentrations of GHRP-6. Maturation rates were assessed during two days of culture, and compared against a blastocyst media (single-step culture) as control group and another IVM media, human tubal fluid (HTF) 10%, as the sham group. Additionally, the expression levels of two genes associated with nuclear and cytoplasmic maturation were compared in the number of 164 GV oocytes randomly cultured in the most effective concentration of GHRP-6, control and sham groups for 24 hours, using real-time polymerase chain reaction (PCR). Results: The optimal concentration of GHRP-6 for the IVM procedure was determined to be 75 ng/ml, resulting in a maturation rate of 70% on the first day and 80% on the second day. These results surpassed those of other culture media on both days. Real-time PCR data indicated that, despite the early appearance of the first polar body (PB1) on 24h of culture, the Ghrelin agonist did not elevate the expression levels of Conclusion: In summary, while GHRP-6 showed potential in promoting nucleonic maturation by significantly inducing the appearance of PB1 between GVs within 24 hours, it did not exhibit statistically significant improvements in cytoplasmic maturation in metaphase 2 oocytes (MII) during this timeframe.
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