SynthesisInternational journal of fertility & sterility2025
Association of Interleukin-33 with Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis Study.
Synthesis in International journal of fertility & sterility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Recurrent pregnancy loss (RPL) is a condition in which a woman experiences two or more consecutive miscarriages before reaching 20 weeks of gestation. The present study was designed to explore the potential link between the interleukin (IL)-33 and RPL. To achieve this goal, we conducted a comprehensive search across the ISI, PubMed, Embase, and Scopus databases. Materials and Methods: We reviewed studies that examined the relationship between specific IL-33 polymorphisms and RPL using the appropriate keywords. The comparator in our study consisted of a control group that included women without RPL. This group was used to assess the differences in genetic polymorphisms and IL-33 serum levels compared to women who experienced RPL. We analyzed the collected data using a random-effects model in STATA (version 14). Five case-control studies were eligible, yielding a total sample size of 1,831 participants (891 cases and 940 controls). Results: The results revealed a significant association between the GG genotype of IL-33 polymorphisms rs16924159 and rs1929992 [odds ratio (OR)=0.72, 95% confidence intervals (CI)=0.51-1.02, I Conclusion: Our findings demonstrate an association between the GG genotype of IL-33 polymorphisms and an increased risk of RPL. Moreover, higher serum levels of IL-33 are likely protective against RPL.
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