Evidence map›Paper›PMID 41090417›Full record

ReviewInternational journal of fertility & sterility2025

The Role of Nutrition in Endometriosis Prevention and Management: A Comprehensive Review.

R Muharam, Edward Christopher Yo, Alisha Nurdya Irzanti, Kresna Mutia, Kanadi Sumapraja, Achmad Kemal Harzif, Gita Pratama, Mila Maidarti, Budi Wiweko, Andon Hestiantoro

Abstract readReview
In one paragraph

Review in International journal of fertility & sterility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

R MuharamReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. Email: Muharam@ui.ac.id.
Edward Christopher YoReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Alisha Nurdya IrzantiReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Kresna MutiaHuman Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Kanadi SumaprajaReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Achmad Kemal HarzifReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Gita PratamaReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Mila MaidartiReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.ORCID 0000-0002-1046-957X
Budi WiwekoReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Andon HestiantoroReproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia -dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis is a chronic gynecological condition defined by the ectopic presence of endometrial-like tissue outside the uterine cavity, often resulting in debilitating symptoms and significant impacts on quality of life. While the exact etiology of endometriosis remains elusive, emerging evidence suggests that diet and nutrition may play a crucial role in its pathogenesis and management. This comprehensive review explores the complex interplay between various food substances and endometriosis, summarizing the latest research findings on both risk-enhancing and protective nutritional factors. Notably, consumption of alcohol, red and processed meats, foods high in saturated and trans fats, and excessive caffeine has been correlated with increased systemic inflammation and hormonal dysregulation-key mechanisms implicated in endometriosis pathogenesis. In contrast, nutrients such as antioxidants, B-complex vitamins, vitamin D, calcium, polyunsaturated fatty acids (PUFAs, particularly omega-3 and omega-6), and dietary fiber have shown promise in exerting anti-inflammatory and protective effects against endometriosis. The review emphasizes the importance of promoting a balanced and nutritious diet rich in anti-inflammatory and antioxidant-rich food while limiting the intake of pro-inflammatory substances for individuals with endometriosis. In addition to dietary interventions, lifestyle modifications, including regular physical activity, stress management, and optimizing sleep hygiene, are highlighted as integral components of comprehensive treatment plans for endometriosis patients. Further research is required to clarify the precise mechanisms underlying the relationship between diet and endometriosis and to establish evidence-based dietary recommendations personalized for patients with endometriosis.

Indexed as

DietEndometriosisinflammatory factorsNutritionprotective factors

Identifiers

PMID41090417
PMCPMC12530228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.