SynthesisClinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery2026
Is Verapamil Effective for Treating Patients With Chronic Rhinosinusitis With Nasal Polyps? A Systematic Review.
Synthesis in Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Is Verapamil Effective for Treating Patients With Chronic Rhinosinusitis With Nasal Polyps? A Systematic Review.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIdentify and summarise the evidence on the efficacy of low-dose verapamil use for adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
methodsTwo reviewers independently searched the data sources until the 28th of December 2023. From 262 studies identified, PRISMA guidelines were implemented to include three randomised controlled trials that used verapamil for patients diagnosed with CRSwNP. Primary endpoints were extracted, including quality-of-life questionnaires and imaging gradings.
resultsAcross 116 participants, all three studies showed statistically significant improvement in the subjective scores of patients who experienced symptoms in the verapamil group. The mean differences between the two intervention groups and placebo in SNOT-22 were -19.17 (95% CI: -30.76 to -7.58) and -27.7 (95% CI: -49.36 to -6.05). On the objective metrics, statistically significant improvement in TNPS or LMS between groups was seen in two out of the three studies (0.01 [p = 0.001], -5.2 [p = 0.02]).
conclusionAlthough verapamil usage resulted in significant improvements in the subjective and objective measurements of the severity of CRSwNP, the current evidence is insufficient to support widespread usage of verapamil for CRSwNP. Further studies should focus on recruiting a clinically significant number of patients, while ensuring robustness and homogeneity in the methodological design.
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