ArticlePhysiological reports2025
Identification of FGF21-inducing rare sugars that reduces sugar appetite in male BL/6 mice.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Fibroblast growth factor 21-inducing rare sugars prevent diet-induced obesity in male BL/6 mice.Endocrine journal · 2026Article
- Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Identification of FGF21-inducing rare sugars that reduces sugar appetite in male BL/6 mice.Physiological reports · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Dietary sugars induce the secretion of hepatic fibroblast growth factor 21 (FGF21) and subsequently activate FGF21-sensing oxytocin neurons to suppress sugar intake. We aimed to identify FGF21-inducing rare sugars as substitutes for obesogenic dietary sugars and to test their ability to suppress sugar appetite in BL/6 mice. We have identified D-allulose, D-tagatose, and D-sorbitol as potent FGF21-inducers in mouse primary hepatocytes. All three compounds were confirmed to induce FGF21 secretion and subsequently activate oxytocin neurons in mice. FGF21-inducing rare sugars administered by gastric gavage to mice reduced sugar intake, and mixing these sugars with sucrose solution significantly reduced their intake and preference in mice. The long-term lick analyses showed that an FGF21-inducing sugar made the solution palatable, but reduced the appetite for the sugar solution and prolonged the ingestion interval in mice. Therefore, using these sugars as substitutes for obesogenic dietary sugars may help to curve sugar appetite and reduce sugar intake.
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