Evidence map›Paper›PMID 41090246›Full record

ArticlePathology international2025

Malignant Potential of Thyroid Follicular Nodular Disease With Solid/Trabecular Components: A Case Report.

Mayu Ueda, Katsuya Matsuda, Yusuke Mori, Hirokazu Kurohama, Hiroyuki Mishima, Koh-Ichiro Yoshiura, Norisato Mitsutake, Hisakazu Shindo, Shinya Sato, Hiroyuki Yamashita and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mayu UedaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Nagasaki, Japan.
Katsuya MatsudaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Nagasaki, Japan.ORCID https://orcid.org/0000-0001-7345-2014
Yusuke MoriYamashita Thyroid Hospital, Fukuoka, Fukuoka, Japan.
Hirokazu KurohamaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Nagasaki, Japan.
Hiroyuki MishimaDepartment of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Nagasaki, Japan.ORCID https://orcid.org/0000-0001-5050-2509
Koh-Ichiro YoshiuraDepartment of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Nagasaki, Japan.
Norisato MitsutakeThyroid Cancer Collaborative Research Center, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Nagasaki, Japan.
Hisakazu ShindoYamashita Thyroid Hospital, Fukuoka, Fukuoka, Japan.
Shinya SatoYamashita Thyroid Hospital, Fukuoka, Fukuoka, Japan.
Hiroyuki YamashitaYamashita Thyroid Hospital, Fukuoka, Fukuoka, Japan.ORCID https://orcid.org/0009-0001-0805-8886
Atsushi KawakamiDepartment of Endocrinology and Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan.
Masahiro NakashimaDepartment of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Nagasaki, Japan.ORCID https://orcid.org/0000-0002-9036-8735

Funding

This study was funded by the Atomic Bomb Disease Institute, Nagasaki University, and the Program of the Network-Type Joint Usage/Research Center for Radiation Disaster Medical Science.
6 · The paper itself

Abstract

Although rare, thyroid follicular nodular disease (TFND) may exhibit a nodule-in-nodule (NN) appearance with solid/trabecular (ST) components (STc). While the STc has histologically aggressive features compared to the outer nodule (Out-N) in TFND, its pathological significance remains unclear. We present a case of TFND with STc in a 63-year-old man who developed skin implantation and lung metastases 3 years after lobectomy. Histologically, the skin tumor resembled STc with high mitotic activity. Molecular analysis revealed EZH1 mutations in both the Out-N and STc of TFND, while KRAS and TERT promoter mutations were restricted to STc and the skin tumor. These findings suggest that the STc of NN may be a precursor to poorly differentiated thyroid carcinoma arising from well-differentiated components through stepwise mutations. This case highlights the malignant potential of certain Noninvasive TFNDs and suggests the need for further analyses to clarify this hypothesis and reconsider their classification and management.

Indexed as

Skin NeoplasmsThyroid NeoplasmsThyroid NoduleHumansLung NeoplasmsMaleMiddle AgedMutationProto-Oncogene Proteins p21(ras)Proto-Oncogene Proteins p21(ras)Cancer gene panelfollicular thyroid carcinomanodule‐in‐noduleST componentsTERT promoterthyroid follicular nodular disease

Identifiers

PMID41090246
PMCPMC12747683

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.