ArticleImmunity, inflammation and disease2025
Pathogenic Potential of Invasive Mucosa-Associated Klebsiella pneumoniae Isolates in Ulcerative Colitis: Characterization of Virulence Factors and Inflammatory Response.
Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cross-cohort resistome and virulome gradients structure the colorectal cancer microbiome.NPJ biofilms and microbiomes · 2026Article
- Short-chain fatty acids in ulcerative colitis: integrating metabolic fate, dynamic biomarkers, and precision delivery.Frontiers in nutrition · 2026Review
- Intestinal mucus acts as a nutrient source and signal forMicrobiome research reports · 2026Article
- Pathogenic Potential of Invasive Mucosa-Associated Klebsiella pneumoniae Isolates in Ulcerative Colitis: Characterization of Virulence Factors and Inflammatory Response.Immunity, inflammation and disease · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundKlebsiella pneumoniae has emerged as an opportunistic pathobiont potentially exacerbating ulcerative colitis (UC) through virulence-mediated inflammation. However, the pathogenic role of invasive mucosa-associated K. pneumoniae in UC remains underexplored. This study characterizes virulence factors and inflammatory responses in K. pneumoniae isolates from UC patients to elucidate their contribution to disease progression.
methodsMucosa-associated K. pneumoniae isolates (n = 62) from UC patients were compared to non-UC controls. Virulence genes, including kfu, magA, fimH, mrkD, rmpA, ybtS, iutA, iroN, hcp, and vgrG, were investigated via PCR. Adhesion, invasion, and intracellular survival were assessed in Caco-2 and THP-1 cells. The relative expression levels of the NOD1, NOD2, STAT1, and NF-κB genes were assessed using real-time quantitative PCR. The concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-8 (IL-8) were quantified with enzyme-linked immunosorbent assay (ELISA) kits.
resultsUC-associated K. pneumoniae isolates exhibited higher prevalence of adhesion/invasion genes (e.g., fimH in 77.4% vs. 46.6%) and enhanced adhesive/invasive phenotypes (29% adherent, 16.1% invasive) compared to controls. These strains lacked hypervirulence markers (rmpA, magA) but aligned with classical virulent profiles. Invasive isolates upregulated NOD1, NOD2, and STAT1 expression and significantly increased IL-8 secretion (p < 0.05), amplifying pro-inflammatory responses.
conclusionInvasive mucosa-associated K. pneumoniae in UC display distinct virulence traits that promote epithelial invasion and inflammation, potentially driving disease exacerbation. Targeting these pathobionts offers a promising avenue for novel UC therapies.
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