Evidence map›Paper›PMID 41090188›Full record

ReviewPhysics and imaging in radiation oncology2025

Radiological response assessment after stereotactic body radiotherapy for spine metastases using magnetic resonance imaging: a systematic review.

Keivan Daneshvar, Mohammadamin Shahrbaf, Johannes Heverhagen, Katarina Bryjova, Daniel M Aebersold, Pejman Jabehdar Maralani, Arjun Sahgal, Matthias Guckenberger, Hossein Hemmatazad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Maintaining quality of scientific peer-review and publishing inPhysics and imaging in radiation oncology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keivan DaneshvarDepartment of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Switzerland.
Mohammadamin ShahrbafDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Johannes HeverhagenDepartment of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Switzerland.
Katarina BryjovaDepartment of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Switzerland.
Daniel M AebersoldDepartment of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Switzerland.
Pejman Jabehdar MaralaniDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada.
Arjun SahgalDepartment of Radiation Oncology, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada.
Matthias GuckenbergerDepartment of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Hossein HemmatazadDepartment of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Magnetic resonance imaging (MRI) plays a central role in evaluating treatment response after stereotactic body radiotherapy (SBRT) for spinal metastases. However, current guidelines focus mainly on conventional MRI sequences and lack standardized, comprehensive criteria for post-treatment assessment. This systematic review aimed to summarize available evidence on MRI-based response assessment following spine SBRT, emphasizing the potential of advanced MRI techniques and computational tools to improve clinical decision-making. Materials and methods: We systematically searched PubMed, Scopus, Web of Science, and Embase from their inception to August 1, 2024. Two reviewers independently screened studies on MRI-based response assessment after SBRT for spinal metastases, evaluated eligibility, and extracted data on MRI techniques, response criteria, imaging biomarkers, and clinical outcomes. Results: Thirteen studies met the inclusion criteria. Tumor volume changes assessed by sagittal T1-weighted MRI, with a minimum detectable difference of approximately 11 %, were essential for evaluating local control. T2 signal alterations and reductions in dynamic contrast-enhanced (DCE) MRI perfusion parameters, such as K Conclusions: MRI provides essential morphological and functional biomarkers for response assessment after spine SBRT. Standardized, multi-parametric MRI protocols and computational tools are needed to optimize patient care.

Indexed as

Magnetic resonance imagingResponse assessmentSpinal metastasesStereotactic body radiotherapy

Identifiers

PMID41090188
PMCPMC12517103

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.