ArticleFrontiers in medicine2025
Digital localization of intraoperative samples enhances margin analysis precision in oral squamous cell carcinoma.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Influence of Formaldehyde Fixation Media on the Raman Spectroscopic Analysis of Oral Squamous Cell Carcinoma.Journal of biophotonics · 2026Article
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7 authors.
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Abstract
Objectives: The intraoperative margin assessment technique enhances local control of Oral Squamous Cell Carcinoma (OSCC). However, the standard frozen section analysis (FSA) procedure does not allow precise interpretation of the final histopathological results. For this reason, we have developed a modified intraoperative margins (IM) assessment protocol using virtual 3D images of resected OSCC. Material and methods: The pilot study included 10 patients with OSCC located in the floor of the mouth (FOM, Results: By analyzing virtual OSCC images, we demonstrated the effectiveness of a modified IM assessment methodology. In one case study, the oncological council disqualified the patient from adjuvant radiotherapy. Conclusion: Leveraging the OSCC's virtual mapping capabilities and the modified IM pathology methodology, we developed an IM evaluation protocol that enables the incorporation of IM width into the OSCC's microscopic excision margin, thereby significantly enhancing the diagnostic value and precision of the final OSCC histopathology results.
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