ArticleFrontiers in medicine2025
Association between physical activity and chronic disease multimorbidity patterns in Chinese middle-aged and older adults.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The growing burden of chronic disease multimorbidity in an aging population highlights the need to promote physical activity as a key strategy for disease management. This study aimed to explore the patterns of chronic comorbidities and their association with physical activity in Chinese middle-aged and older adults. Methods: A cross-sectional study was conducted using data from the 2020 China Health and Retirement Longitudinal Study. Latent class analysis was applied to identify distinct multimorbidity patterns among middle-aged and older adults, whereas multivariate logistic regression was used to analyze the influencing factors. The χ Results: Chronic disease multimorbidities were categorized into three classes: Class 1 (Metabolic Pattern), Class 2 (Multisystem Pattern), and Class 3 (Hypertension-Digestive-Musculoskeletal Pattern). Engagement in moderate-intensity physical activity was associated with a lower odds of Multisystem Pattern (OR = 0.74, 95% CI: 0.70∼0.91). Engagement in high-intensity physical activity was linked to a lower odds of both Metabolic Pattern (OR = 0.75, 95% CI: 0.68∼0.83) and Multisystem Pattern (OR = 0.75, 95% CI: 0.67∼0.84) diseases but was associated with a higher odds of Hypertension-Digestive-Musculoskeletal Pattern (OR = 1.46, 95% CI: 1.34∼1.59) diseases. Conclusion: Moderate physical activity reduces the risk of Multisystem Pattern and plays an essential role in preventing and managing metabolic disorders. Although high-intensity physical activity can reduce the risk of metabolic disorders and Multisystem Pattern, excessive physical activity may increase the risk of Hypertension-Digestive-Musculoskeletal Pattern.
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