The effect of dietary tryptophan supplementation, and an oral tryptophan challenge, on urinary excretion of 5-hydroxyindoleacetic acid in domestic dogs.

Chloe Cheung, Jess Rigling, Bernadette Stang, Craig Ruaux

Abstract read

In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chloe CheungUniversity Veterinary Teaching Hospital Sydney, Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW, Australia.

Jess RiglingVeterinary Clinical Sciences, Oregon State University, Corvallis, OR, United States.

Bernadette StangVeterinary Clinical Sciences, Oregon State University, Corvallis, OR, United States.

Craig RuauxUniversity Veterinary Teaching Hospital Sydney, Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic enteropathies, commonly referred to as inflammatory bowel disease, are multi-factorial disorders that affect a substantial proportion of both the human population and companion animals. There is an emerging body of evidence suggesting that alterations in serotonin metabolism may contribute to the development of inflammatory bowel disease in humans. 5-Hydroxyindole acetic acid (5-HIAA) is a major metabolite of serotonin which undergoes renal excretion, providing a non-invasive indicator of serotonin metabolism. This study validated a commercial ELISA assay for 5-HIAA for use in canines and investigated the effect of dietary tryptophan supplementation and tryptophan challenge on the excretion of 5-HIAA in healthy dogs (

Indexed as

5-hydroxyindoleacetic acidchronic enteropathyinflammatory bowel diseaseserotonintryptophan

Identifiers

PMID41090076

DOI10.3389/fvets.2025.1634940

PMCPMC12515618

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.