ArticleFrontiers in neurology2025
Electroencephalogram prediction of propofol effects on neuromodulation in disorders of consciousness.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07533370 (Extended Emergence Trajectory on Post-Anesthesia Care Units Events in Ambulatory Lower-Extremity Orthopedic Surgery), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Extended Emergence Trajectory on Post-Anesthesia Care Units Events in Ambulatory Lower-Extremity Orthopedic Surgery: A Randomized Controlled Trial
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of neuromodulation and multimodal therapies for traumatic brain injury-induced disorders of consciousness: an updated umbrella review.Frontiers in neurologyPooled it
- Bridging neural circuits and clinical outcomes: a novel framework for perioperative disturbances of consciousness and cognition.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to characterize electroencephalogram (EEG) responses to low-dose propofol anesthesia in patients with disorders of consciousness (DoC) of distinct etiologies-traumatic brain injury (TBI), anoxic ischemic encephalopathy (AIE), and cerebrovascular accident (CVA)-and explore their prognostic relevance for recovery after spinal cord stimulation (SCS). Methods: A retrospective cohort of 40 DoC patients (TBI: 15, CVA: 14, AIE: 11) undergoing SCS under propofol anesthesia was analyzed. Pre- and post-anesthesia 19-lead EEG recordings were evaluated for power spectral density (PSD) in δ (0.5-4 Hz), θ (4-8 Hz), α (8-13 Hz), β (13-30 Hz), and γ (30-45 Hz) bands, alongside permutation entropy (PE). Consciousness levels were quantified using the Coma Recovery Scale-Revised (CRS-R) preoperatively and 3 months post-SCS. Etiology-stratified analyses compared neurophysiological and clinical outcomes. Results: Propofol universally suppressed β- ( Conclusion: Propofol-induced EEG modulation reflects etiology-dependent neural network vulnerabilities in DoC. TBI/CVA patients demonstrated entropy reduction linked to clinical recovery, suggesting transient network stabilization that may enhance SCS efficacy. In contrast, AIE-associated static dynamics imply irreversible structural damage. Integrated PSD/PE analysis holds prognostic potential for predicting SCS responsiveness, particularly in TBI/CVA cohorts. These findings advocate etiology-tailored neuromodulation strategies, though multicenter validation is imperative for clinical translation.
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